From the Faculty of Health Sciences (Currie), Department of Kinesiology and Physical Education, Faculty of Arts and Science (Copeland), and Canadian Centre for Behavioural Neuroscience (Metz), University of Lethbridge, Lethbridge, Alberta; College of Medicine (Moon-Riley), University of Saskatchewan, Saskatoon, Saskatchewan; and Department of Mathematics and Statistical Sciences, Faculty of Science (Davies), University of Alberta, Edmonton, Alberta, Canada.
Psychosom Med. 2020 Jan;82(1):99-107. doi: 10.1097/PSY.0000000000000754.
This study aimed to examine the association between racial discrimination and allostatic load (AL) and whether this association was moderated by cultural continuity among Indigenous adults.
Data were collected from Indigenous adults attending university in a small city in western Canada between 2015 and 2017 (mean age = 27.8 years). The Experience of Discrimination Situation Score and the Vancouver Index Enculturation Subscale were used to assess racial discrimination and cultural continuity, respectively. AL was measured as a composite of seven biomarkers assessing neuroendocrine, cardiovascular, metabolic, and immune system function. Bias-corrected and accelerated bootstrapped linear regression models were used to examine associations adjusting for confounders (n = 104; 72.5% women).
Across the full sample, racial discrimination was associated with a linear, dose-response increase in AL score after adjustment for confounders. Among adults with low cultural continuity, past-year discrimination was associated with increased AL and explained 22% (adjusted R) of the variance in AL score. Taken together, the full model including age, sex, and income explained 38% of the variance in AL score in this subgroup. Among adults with high cultural continuity, racial discrimination was not associated with AL, whereas age remained significant and explained 13% of the variance in AL score.
Past-year racial discrimination was associated with early and more pronounced wear and tear on stress response systems among Indigenous adults relative to peers. Indigenous cultural continuity served as an important buffer that promoted biological resilience against the adverse effects of racial discrimination on physiologic regulation among Indigenous adults.
本研究旨在探讨种族歧视与应激反应系统负荷（AL）之间的关系，并检验文化连续性是否会对这种关系产生调节作用。
本研究的数据来自于 2015 年至 2017 年间在加拿大西部一个小城市上大学的土著成年人（平均年龄为 27.8 岁）。采用歧视经历情境评分和温哥华指数本土化亚量表分别评估种族歧视和文化连续性。AL 作为评估神经内分泌、心血管、代谢和免疫系统功能的七个生物标志物的综合指标进行测量。采用偏倚校正和加速 bootstrap 线性回归模型，在调整混杂因素（n=104；72.5%为女性）后，检验各变量之间的关联。
在全样本中，在调整混杂因素后，种族歧视与 AL 评分的线性、剂量反应增加相关。在文化连续性较低的成年人中，过去一年的歧视与 AL 的增加相关，解释了 AL 评分方差的 22%（调整后的 R²）。总体而言，包括年龄、性别和收入在内的全模型解释了该亚组中 AL 评分方差的 38%。在文化连续性较高的成年人中，种族歧视与 AL 无关，而年龄仍然是显著的，解释了 AL 评分方差的 13%。
过去一年的种族歧视与土著成年人相对于同龄人更早、更明显的应激反应系统磨损有关。土著文化连续性是一种重要的缓冲机制，有助于促进生物弹性，减轻种族歧视对土著成年人生理调节的不利影响。
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