Bedsworth Meredith B, Harris Erica M, Vacchiano Charles A, Thompson Julie A, Grant Stuart A, Goode Victoria M
is a graduate from the Duke University School of Nursing in Durham, North Carolina.
is in the Duke University Hospital Department of Anesthesiology, Durham, North Carolina.
AANA J. 2019 Oct;87(5):357-363.
Improved understanding of the monitoring and dosing practices of anesthesia providers regarding neuromuscular blockade is necessary. The use of subjective methods such as peripheral nerve stimulation and clinical assessment tests can increase the risk of residual neuromuscular blockade and adverse postoperative outcomes. Quantitative monitoring of neuromuscular blockade is an alternative tool to peripheral nerve stimulation to guide neuromuscular blockade; however, it is rarely used by providers. We developed an initiative to improve anesthesia providers' knowledge of neuromuscular blockade pharmacology, physiology, monitoring, and management. After the initiative, an analysis assessed for practice change regarding the use of quantitative monitoring and dosing of neuromuscular blocking agents and neostigmine. The use of quantitative monitoring increased significantly from 14.0% in the preinitiative group to 48.0% after the initiative (P < .001). The least squares mean 95% effective dose (ED) neuromuscular blocking agents dose was compared between pre-initiative and postinitiative groups, and case length was a significant predictor for patients receiving the highest neuromuscular blocking agents doses. Neostigmine doses were compared between preinitiative and postinitiative groups, and body mass index was a significant predictor of the least squares mean neostigmine dose (P = .002) and the likelihood of receiving a high neostigmine dose (odds ratio = 0.911, 95% CI = 0.870-0.955).
有必要更好地了解麻醉医生在神经肌肉阻滞方面的监测和给药实践。使用外周神经刺激和临床评估测试等主观方法会增加残余神经肌肉阻滞和术后不良后果的风险。神经肌肉阻滞的定量监测是一种可替代外周神经刺激来指导神经肌肉阻滞的工具;然而,麻醉医生很少使用它。我们发起了一项倡议,以提高麻醉医生对神经肌肉阻滞药理学、生理学、监测和管理的认识。倡议实施后,进行了一项分析,评估在神经肌肉阻滞剂和新斯的明的定量监测及给药方面的实践变化。定量监测的使用从倡议前组的14.0%显著增加到倡议后的48.0%(P <.001)。比较了倡议前组和倡议后组神经肌肉阻滞剂的最小二乘均值95%有效剂量(ED),病例时长是接受最高神经肌肉阻滞剂剂量患者的一个显著预测因素。比较了倡议前组和倡议后组的新斯的明剂量,体重指数是最小二乘均值新斯的明剂量的一个显著预测因素(P =.002)以及接受高剂量新斯的明可能性的预测因素(比值比 = 0.911,95%可信区间 = 0.870 - 0.955)。