睾丸生殖细胞癌是否依赖于雌激素？内分泌干扰化学品的作用。

Is Testicular Germ Cell Cancer Estrogen Dependent? The Role of Endocrine Disrupting Chemicals.

机构信息

Université Côte d'Azur, CHU de Nice, Service d'Endocrinologie, Diabétologie et Médecine de la Reproduction, Hôpital de l'Archet, France.

Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, INSERM U1065/UNS, Centre Méditerranéen de Médecine Moléculaire, Equipe, France.

出版信息

Endocrinology. 2019 Dec 1;160(12):2981-2989. doi: 10.1210/en.2019-00486.

DOI:10.1210/en.2019-00486

PMID:31617897

Abstract

Testicular germ cell cancer (TGCC) is the most frequent cancer of the young male, with an increasing incidence worldwide. The pathogenesis and reasons for this increase remain unknown. However, epidemiological and experimental data have suggested that, similar to genital malformations and sperm impairment, it could result from the interaction of genetic and environmental factors including fetal exposure to endocrine-disrupting chemicals (EDCs) with estrogenic effects. In this review, we analyze the expression of classic and nonclassic estrogen receptors by TGCC cells, the way they may influence germ cell proliferation induced by EDCs, and discuss how this estrogen dependency supports the developmental and environmental hypothesis.

摘要

睾丸生殖细胞癌（TGCC）是年轻男性最常见的癌症，全球发病率呈上升趋势。其发病机制和原因尚不清楚。然而，流行病学和实验数据表明，与生殖畸形和精子损伤类似，它可能是遗传和环境因素相互作用的结果，包括胎儿暴露于具有雌激素效应的内分泌干扰化学物质（EDCs）。在这篇综述中，我们分析了 TGCC 细胞中经典和非经典雌激素受体的表达，它们可能影响 EDC 诱导的生殖细胞增殖的方式，并讨论了这种雌激素依赖性如何支持发育和环境假说。