Department of Internal Medicine, Division of Diabetology, Endocrinology and Nephrology, University Hospital Tübingen, Tübingen, Germany,
Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany,
Kidney Blood Press Res. 2019;44(6):1383-1391. doi: 10.1159/000503288. Epub 2019 Oct 16.
Unplanned start of renal replacement therapy is common in patients with end-stage renal disease and often accomplished by hemodialysis (HD) using a central venous catheter (CVC). Urgent start using peritoneal dialysis (PD) could be an alternative for some of the patients; however, this requires a hospital-based PD center that offers a structured urgent start PD (usPD) program.
In this prospective study, we describe the implementation of an usPD program at our university hospital by structuring the process from presentation to PD catheter implantation and start of PD within a few days. For clinical validation, we compared the patient flow before (2013-2015) and after (2016-2018) availability of usPD.
In the 3 years before the availability of usPD, 14% (n = 12) of incident PD patients (n = 87) presented in an unplanned situation and were initially treated with HD using a CVC. In the 3 years after implementation of the usPD program, 18% (n = 18) of all incident PD patients (n = 103) presented in an unplanned situation of whom n = 12 (12%) were treated with usPD and n = 6 (6%) with initial HD. usPD significantly reduced the use of HD by 57% (p = 0.0005). Hospital stay was similar in patients treated with usPD (median 9 days) compared to those with elective PD (8 days), and significantly lower than in patients with initial HD (26 days, p = 0.0056).
Implementation of an usPD program reduces HD catheter use and hospital stay in the unplanned situation.
终末期肾病患者常需要进行肾脏替代治疗,其中血液透析(HD)常使用中心静脉导管(CVC)来紧急开始治疗。对于某些患者,紧急开始腹膜透析(PD)可能是一种替代方法;然而,这需要一个提供结构化紧急 PD(usPD)计划的医院 PD 中心。
在这项前瞻性研究中,我们描述了在我们的大学医院实施 usPD 计划的过程,从患者就诊到 PD 导管植入和 PD 开始,将时间缩短到几天内。为了临床验证,我们比较了在有 usPD 之前(2013-2015 年)和之后(2016-2018 年)的患者流程。
在有 usPD 之前的 3 年中,14%(n=12)的新 PD 患者(n=87)出现无计划情况,并最初使用 CVC 进行 HD 治疗。在实施 usPD 计划后的 3 年中,18%(n=18)的所有新 PD 患者(n=103)出现无计划情况,其中 n=12(12%)接受 usPD 治疗,n=6(6%)接受初始 HD 治疗。usPD 显著降低了 HD 的使用率(p=0.0005)。与接受选择性 PD 治疗的患者(n=8 天)相比,接受 usPD 治疗的患者住院时间相似(中位数 9 天),与接受初始 HD 治疗的患者相比(n=26 天,p=0.0056)显著降低。
实施 usPD 计划可减少无计划情况下 HD 导管的使用和住院时间。