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终末期肾病老年患者腹膜透析导管植入术后立即开始非计划性腹膜透析

Unplanned Start on Peritoneal Dialysis Right after PD Catheter Implantation for Older People with End-Stage Renal Disease.

作者信息

Povlsen Johan V, Sørensen Anette Bagger, Ivarsen Per

机构信息

Dept. Renal Medicine C, Aarhus University Hospital, Aarhus, Denmark

Dept. Renal Medicine C, Aarhus University Hospital, Aarhus, Denmark.

出版信息

Perit Dial Int. 2015 Nov;35(6):622-4. doi: 10.3747/pdi.2014.00347.

Abstract

Unplanned start on dialysis remains a major problem for the dialysis community worldwide. Late-referred patients with end-stage renal disease (ESRD) and urgent need for dialysis are overrepresented among older people. These patients are particularly likely to be started on in-center hemodialysis (HD), with a temporary vascular access known to be associated with excess mortality and increased risks of potentially lethal complications such as bacteremia and central venous thrombosis or stenosis.The present paper describes in detail our program for unplanned start on automated peritoneal dialysis (APD) right after PD catheter implantation and summarizes our experiences with the program so far. Compared with planned start on PD after at least 2 weeks of break-in between PD catheter implantation and initiation of dialysis, unplanned start may be associated with a slight increased risk of mechanical complications but apparently no detrimental effect on mortality, peritonitis-free survival, or PD technique survival.In our opinion and experience, the risk of serious complications associated with the implantation and immediate use of a PD catheter is less than the risk of complications associated with unplanned start on HD with a temporary central venous catheter (CVC). Unplanned start on APD is a gentle, safe, and feasible alternative to unplanned start on HD with a temporary CVC that is also valid for the late-referred older patient with ESRD and urgent need for dialysis.

摘要

透析的非计划起始仍是全球透析领域的一个主要问题。晚期转诊的终末期肾病(ESRD)患者且急需透析的情况在老年人中占比过高。这些患者尤其可能开始接受中心血液透析(HD),其临时血管通路已知与过高死亡率以及诸如菌血症、中心静脉血栓形成或狭窄等潜在致命并发症风险增加有关。本文详细描述了我们在植入腹膜透析导管后立即进行自动腹膜透析(APD)非计划起始的方案,并总结了我们到目前为止在该方案中的经验。与在腹膜透析导管植入和透析开始之间至少有2周磨合期后进行的计划内腹膜透析起始相比,非计划起始可能与机械并发症风险略有增加相关,但显然对死亡率、无腹膜炎生存期或腹膜透析技术生存期没有不利影响。根据我们的观点和经验,与植入并立即使用腹膜透析导管相关的严重并发症风险低于与使用临时中心静脉导管(CVC)进行血液透析非计划起始相关的并发症风险。对于晚期转诊且急需透析的ESRD老年患者,腹膜透析非计划起始是使用临时中心静脉导管进行血液透析非计划起始的一种温和、安全且可行的替代方案。

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