脑-胰腺信号轴将尼古丁与糖尿病联系起来。
Brain-to-pancreas signalling axis links nicotine and diabetes.
出版信息
Nature. 2019 Oct;574(7778):336-337. doi: 10.1038/d41586-019-02975-w.
Abstract
The discovery of a signalling axis that connects nicotine responses in the brain with glucose metabolism by the pancreas sheds light on why cigarette smoking increases the risk of diabetes.
摘要
这一发现揭示了为什么吸烟会增加糖尿病的风险
一条信号通路将大脑中尼古丁的反应与胰腺的葡萄糖代谢联系起来。
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Nature. 2019 Oct;574(7778):372-377. doi: 10.1038/s41586-019-1653-x. Epub 2019 Oct 16.
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Nicotine addiction.尼古丁成瘾
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Expression of the diabetes-associated gene TCF7L2 in adult mouse brain.糖尿病相关基因 TCF7L2 在成年鼠脑中的表达。
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Consequences of smoking for body weight, body fat distribution, and insulin resistance.吸烟对体重、体脂分布和胰岛素抵抗的影响。
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It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood.并非“非此即彼”：烟碱型乙酰胆碱受体的激活和脱敏都与尼古丁成瘾及情绪相关行为有关。
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