Department of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9077, USA.
J Comp Neurol. 2009 Dec 20;517(6):925-39. doi: 10.1002/cne.22199.
Polymorphisms of the gene TCF7L2 (transcription factor 7-like 2) are strongly associated with the development and progression of type 2 diabetes. TCF7L2 is important in the development of peripheral organs such as adipocytes, pancreas, and the intestine. However, very little is known about its expression elsewhere. In this study we used in situ hybridization histochemistry to show that TCF7L2 has a unique expression pattern in the mouse brain. TCF7L2 is expressed in two distinct populations. First, it is highly expressed in thalamic and tectal structures. Additionally, TCF7L2 mRNA is expressed at moderate to low levels in specific cells of the hypothalamus, preoptic nucleus, and circumventricular organs. Collectively, these patterns of expression suggest that TCF7L2 has distinct functions within the brain, with a general role in the development and maintenance of thalamic and midbrain neurons, and then a distinct role in autonomic homeostasis.
基因 TCF7L2（转录因子 7 样 2）的多态性与 2 型糖尿病的发生和发展密切相关。TCF7L2 在脂肪细胞、胰腺和肠道等外周器官的发育中起着重要作用。然而，关于其在其他部位的表达情况知之甚少。在这项研究中，我们使用原位杂交组织化学技术显示 TCF7L2 在小鼠大脑中有独特的表达模式。TCF7L2 在两种不同的细胞群中表达。首先，它在丘脑和脑结构中高度表达。此外，TCF7L2 mRNA 在下丘脑、视前核和室周器官的特定细胞中以中等至低水平表达。总的来说，这些表达模式表明 TCF7L2 在大脑中有独特的功能，在丘脑和中脑神经元的发育和维持中起一般作用，然后在自主平衡中起独特作用。
