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Hair Depigmentation and Hair Loss in Advanced Melanoma Treated with Combined Immunotherapy and Targeted Therapy.

作者信息

Dimitriou Florentia, Mangana Joanna, Dummer Reinhard

机构信息

Department of Dermatology , University Hospital Zurich, Zurich, Switzerland.

出版信息

Acta Derm Venereol. 2020 Jan 7;100(1):adv00007. doi: 10.2340/00015555-3355.

DOI:10.2340/00015555-3355
PMID:31626322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9128868/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54f1/9128868/6fae7ee9b3a6/ActaDV-100-1-5620-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54f1/9128868/6fae7ee9b3a6/ActaDV-100-1-5620-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54f1/9128868/6fae7ee9b3a6/ActaDV-100-1-5620-g001.jpg

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Hair Depigmentation and Hair Loss in Advanced Melanoma Treated with Combined Immunotherapy and Targeted Therapy.联合免疫疗法和靶向疗法治疗晚期黑色素瘤时的毛发色素脱失和脱发
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RASopathic alopecia: hair changes associated with vemurafenib therapy.RASopathy相关脱发：与维莫非尼治疗相关的毛发变化
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Immune checkpoint inhibitor-related alopecia: Insight into the pathophysiology utilizing non-invasive diagnostic techniques.免疫检查点抑制剂相关脱发：利用非侵入性诊断技术洞察其病理生理学
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Int J Clin Pharm. 2018 Aug;40(4):852-861. doi: 10.1007/s11096-018-0665-1. Epub 2018 Jun 2.
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Ipilimumab prolongs survival in advanced melanoma.伊匹单抗可延长晚期黑色素瘤患者的生存期。
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Secondary haemophagocytic lymphohistiocytosis due to checkpoint inhibitor therapy.检查点抑制剂治疗所致继发性噬血细胞性淋巴组织细胞增生症
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Presence of antibodies to striated muscle and acetylcholine receptor in association with occurrence of myasthenia gravis with myositis and myocarditis in a patient with melanoma treated with an anti-programmed death 1 antibody.在一名接受抗程序性死亡1抗体治疗的黑色素瘤患者中，出现针对横纹肌和乙酰胆碱受体的抗体，并伴有重症肌无力合并肌炎和心肌炎。
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Cytokine release syndrome as an important differential diagnosis of severe skin toxicity with organ damage during switch from immunotherapy to targeted therapy in metastatic melanoma.细胞因子释放综合征是转移性黑色素瘤从免疫治疗转换为靶向治疗期间严重皮肤毒性伴器官损伤的重要鉴别诊断。
Melanoma Res. 2019 Feb;29(1):107-108. doi: 10.1097/CMR.0000000000000544.

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Hair Graying Regulators Beyond Hair Follicle.毛囊之外的头发变白调节因子
Front Physiol. 2022 Feb 24;13:839859. doi: 10.3389/fphys.2022.839859. eCollection 2022.
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Vitiligo-like leukoderma as an indicator of clinical response to immune checkpoint inhibitors in late-stage melanoma patients.白癜风样白化病作为晚期黑色素瘤患者对免疫检查点抑制剂临床反应的指标。

本文引用的文献

1
Cytokine Release Syndrome During Sequential Treatment With Immune Checkpoint Inhibitors and Kinase Inhibitors for Metastatic Melanoma.免疫检查点抑制剂和激酶抑制剂序贯治疗转移性黑色素瘤时的细胞因子释放综合征。
J Immunother. 2019 Jan;42(1):29-32. doi: 10.1097/CJI.0000000000000236.
2
Survival of patients with advanced metastatic melanoma: the impact of novel therapies-update 2017.晚期转移性黑色素瘤患者的生存情况：新型疗法的影响——2017年更新
Eur J Cancer. 2017 Sep;83:247-257. doi: 10.1016/j.ejca.2017.06.028. Epub 2017 Aug 23.
3
Immune and molecular correlates in melanoma treated with immune checkpoint blockade.
J Cancer Res Clin Oncol. 2022 Sep;148(9):2529-2538. doi: 10.1007/s00432-021-03811-3. Epub 2021 Sep 30.
4
Cutaneous Events Associated with Immunotherapy of Melanoma: A Review.黑色素瘤免疫治疗相关的皮肤事件：综述
J Clin Med. 2021 Jul 8;10(14):3047. doi: 10.3390/jcm10143047.
5
Melanoma and Vitiligo: In Good Company.黑素瘤与白癜风：相伴相生。
Int J Mol Sci. 2019 Nov 15;20(22):5731. doi: 10.3390/ijms20225731.
接受免疫检查点阻断治疗的黑色素瘤中的免疫与分子关联
Cancer. 2017 Jun 1;123(S11):2143-2153. doi: 10.1002/cncr.30444.
4
Understanding autoimmunity of vitiligo and alopecia areata.了解白癜风和斑秃的自身免疫性。
Curr Opin Pediatr. 2016 Aug;28(4):463-9. doi: 10.1097/MOP.0000000000000375.
5
Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor.针对程序性死亡受体-1（PD-1）受体的药物所致皮肤不良事件的特征与管理
Eur J Cancer. 2016 Jun;60:12-25. doi: 10.1016/j.ejca.2016.02.010. Epub 2016 Apr 1.
6
Localized Hair Repigmentation in a 91-Year-Old Woman.一名91岁女性的局限性毛发再色素沉着
JAMA Dermatol. 2016 Jan;152(1):81-2. doi: 10.1001/jamadermatol.2015.3812.
7
Immune Checkpoint Blockade in Cancer Therapy.癌症治疗中的免疫检查点阻断疗法
J Clin Oncol. 2015 Jun 10;33(17):1974-82. doi: 10.1200/JCO.2014.59.4358. Epub 2015 Jan 20.
8
Vitiligo-like depigmentation in patients with stage III-IV melanoma receiving immunotherapy and its association with survival: a systematic review and meta-analysis.接受免疫治疗的 III-IV 期黑色素瘤患者出现白癜风样色素脱失及其与生存的关系：系统评价和荟萃分析。
J Clin Oncol. 2015 Mar 1;33(7):773-81. doi: 10.1200/JCO.2014.57.4756. Epub 2015 Jan 20.
9
Alopecia areata with white hair regrowth: case report and review of poliosis.斑秃伴白发再生：病例报告及白发症综述
Dermatol Online J. 2014 Sep 16;20(9):13030/qt1xk5b26v.
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Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.斑秃由细胞毒性 T 淋巴细胞驱动，并可被 JAK 抑制逆转。
Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17.