Donadu Matthew, Usai Donatella, Pinna Antonio, Porcu Tiziana, Mazzarello Vittorio, Fiamma Maura, Marchetti Mauro, Cannas Sara, Delogu Giovanni, Zanetti Stefania, Molicotti Paola
University of Sassari, Sassari, Italy.
CNR, Institute of Biomolecular Chemistry, Li Punti, Sassari, Italy.
J Infect Dev Ctries. 2018 Jan 31;12(1):9-14. doi: 10.3855/jidc.9920.
Lavender is an evergreen shrub native to Northern Africa and other mountainous Mediterranean regions. It grows throughout Southern Europe, the United States, and Australia. Lavender essential oil has been used since ancient times and is known for its anti-inflammatory, antidepressant, antiseptic, antifungal and antimicrobial properties.
in this study, the antimicrobial activity of two Lavender essential oils (Lavanda sumian and Lavanda grosso) against 16 multidrug-resistant P. aeruginosa strains from clinical ocular samples taken from migrant patients has been investigated. The in vitro cytotoxic activity on human Wong-Kilbourne derivative (WKD) conjunctiva cells from healthy patients and nitric oxide synthase (NOS) activity on murine macrophage (J774.1A) were also evaluated.
L. sumian showed lower antimicrobial activity when compared to L. grosso. Both lavender oils tested had no cytotoxic effect at very low concentrations, mostly L. grosso. The essential oils extracted from L. sumian and L. grosso significantly reduced NOS in a cell model.
Increase in drug resistance and lack of new antibiotics may encourage the development of natural antimicrobial treatments.
薰衣草是一种常绿灌木，原产于北非和地中海其他山区。它生长于整个南欧、美国和澳大利亚。薰衣草精油自古以来就被使用，以其抗炎、抗抑郁、防腐、抗真菌和抗菌特性而闻名。
在本研究中，研究了两种薰衣草精油（醒目薰衣草和杂薰衣草）对来自移民患者临床眼部样本的16株多重耐药铜绿假单胞菌菌株的抗菌活性。还评估了对健康患者人Wong-Kilbourne衍生物（WKD）结膜细胞的体外细胞毒性活性以及对小鼠巨噬细胞（J774.1A）的一氧化氮合酶（NOS）活性。
与杂薰衣草相比，醒目薰衣草的抗菌活性较低。两种测试的薰衣草油在非常低的浓度下均无细胞毒性作用，主要是杂薰衣草。从醒目薰衣草和杂薰衣草中提取的精油在细胞模型中显著降低了NOS。
耐药性增加和新抗生素的缺乏可能会促使天然抗菌治疗方法的发展。
