Srinivasan Meera, Ahmad Laura, Bhindi Ravinay, Allahwala Usaid
Royal North Shore Hospital.
North Shore Private Hospital.
Aust Prescr. 2019 Oct;42(5):158-162. doi: 10.18773/austprescr.2019.051. Epub 2019 Oct 1.
Amiodarone is a highly effective antiarrhythmic drug, but can have serious adverse effects, particularly in older patients. If possible it should not be used purely for controlling the heart rate If a prescription for amiodarone is contemplated, particularly for an older patient, consult a cardiologist. Avoid amiodarone in patients with significant conduction system disease, significant liver or pulmonary disease, or hyperthyroidism Regular monitoring of the patient, clinically and biochemically, is required to identify complications at an early, treatable stage. Maintain a high level of suspicion if a patient taking amiodarone is experiencing adverse reactions and presents with new symptoms Consider potential drug interactions when other drugs are prescribed with amiodarone. The effects and toxicities of amiodarone may persist weeks after it is stopped
胺碘酮是一种高效抗心律失常药物,但可能会产生严重不良反应,尤其是在老年患者中。如果可能,不应仅用于控制心率。如果考虑开具胺碘酮处方,特别是给老年患者,应咨询心脏病专家。有严重传导系统疾病、严重肝脏或肺部疾病或甲状腺功能亢进的患者应避免使用胺碘酮。需要对患者进行临床和生化方面的定期监测,以便在早期可治疗阶段识别并发症。如果服用胺碘酮的患者出现不良反应并伴有新症状,要保持高度怀疑。当与胺碘酮合用时,开其他药物时要考虑潜在的药物相互作用。胺碘酮停药后其作用和毒性可能会持续数周。