Prigogina E L, Puchkova G P, Mayakova S A
All-Union Cancer Center Research Center, AMS USSR, Moscow.
Cancer Genet Cytogenet. 1988 Jun;32(2):183-203. doi: 10.1016/0165-4608(88)90281-6.
The leukemic cell karyotype was studied in 103 children with acute lymphoblastic leukemia. An abnormal chromosome pattern was revealed in 81 of 98 patients studied before treatment (82.6%) and in the five children studied in relapse. Aside from specific chromosomal abnormalities defined by the Third International Workshop on Chromosomes in Leukemia, other nonrandom rearrangements were observed, particularly del(14)(q11-13), del(12)(p11-12), and t(1;19)(q22-23;p13), often associated with partial trisomy for 1q. Patients with del(14) had tumorous lymph-nodes or other extramedullary tumors. The course of the disease in these children was rapid. Patients with markers such as Ph, 6q-,14q+, and with a t(4;11) had a low incidence of complete remission and short survival. The most favorable course of the disease was observed in the group of children with over 50 chromosomes in the leukemic cells.
对103例急性淋巴细胞白血病患儿的白血病细胞核型进行了研究。在98例治疗前研究的患者中有81例（82.6%）以及5例复发时研究的患儿显示出异常染色体模式。除了白血病染色体第三次国际研讨会确定的特定染色体异常外，还观察到其他非随机重排，特别是del(14)(q11 - 13)、del(12)(p11 - 12)和t(1;19)(q22 - 23;p13)，常与1q部分三体相关。del(14)的患者有肿瘤性淋巴结或其他髓外肿瘤。这些患儿的病程进展迅速。具有如Ph、6q - 、14q + 标记以及t(4;11)的患者完全缓解率低且生存期短。在白血病细胞中染色体超过50条的患儿组中观察到疾病的最有利病程。
