Bowman M P, Van Doren J, Taper L J, Thye F W, Ritchey S J
Department of Human Nutrition and Foods, Virginia Polytechnic Institute and State University, Blacksburg 24061.
J Nutr. 1988 May;118(5):555-60. doi: 10.1093/jn/118.5.555.
In a controlled feeding situation, male subjects were assigned to one of four treatment groups: low fat (31% of total kcal)/low cholesterol (193 mg/d) (LFLC), low fat/usual cholesterol (504 mg/d) (LFUC), usual fat (46% of total kcal)/low cholesterol (UFLC) and usual fat/usual cholesterol (UFUC) intake. For the first 2 wk of the 10-wk study all subjects consumed the UFUC diet. Subjects consumed experimental diets during wk 3-7 and resumed their customary intake during wk 8-10. Plasma total, high-density-lipoprotein (HDL), low-density-lipoprotein and very-low-density-lipoprotein cholesterol and triglycerides were determined weekly. A significant effect (P less than 0.05) of dietary fat on plasma total and HDL cholesterol was observed between the end of wk 2 and 7. Low fat intake resulted in 17 +/- 2 mg/dL lower total cholesterol and 10 +/- 1 mg/dL lower HDL cholesterol than the usual fat intake. Plasma lipids were not affected either by dietary cholesterol or by any interaction of dietary fat with cholesterol.
在控制饮食的情况下，男性受试者被分为四个治疗组之一：低脂（占总热量的31%）/低胆固醇（193毫克/天）（LFLC）、低脂/正常胆固醇（504毫克/天）（LFUC）、正常脂肪（占总热量的46%）/低胆固醇（UFLC）和正常脂肪/正常胆固醇（UFUC）摄入组。在为期10周的研究的前2周，所有受试者都食用UFUC饮食。受试者在第3至7周食用实验性饮食，并在第8至10周恢复其习惯摄入量。每周测定血浆总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白和极低密度脂蛋白胆固醇以及甘油三酯。在第2周结束至第7周期间，观察到饮食脂肪对血浆总胆固醇和HDL胆固醇有显著影响（P小于0.05）。与正常脂肪摄入相比，低脂摄入导致总胆固醇降低17±2毫克/分升，HDL胆固醇降低10±1毫克/分升。血浆脂质不受饮食胆固醇或饮食脂肪与胆固醇的任何相互作用的影响。
