Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, Maryland 20892.
Cold Spring Harb Perspect Biol. 2020 May 1;12(5):a035279. doi: 10.1101/cshperspect.a035279.
Calcium (Ca) and cyclic AMP (cAMP) signaling cross talk and synergize to stimulate the cardinal functions of exocrine cells, regulated exocytosis, and fluid and electrolyte secretion. This physiological process requires the organization of the two signaling pathways into complexes at defined cellular domains and close placement. Such domains are formed by membrane contact sites (MCS). This review discusses the basic properties of Ca signaling in exocrine cells, the role of MCS in the organization of cell signaling and in cross talk and synergism between the Ca and cAMP signaling pathways and, finally, the mechanism by which the Ca and cAMP pathways synergize to stimulate epithelial fluid and electrolyte secretion.
钙（Ca）和环腺苷酸（cAMP）信号转导相互作用并协同作用，刺激外分泌细胞的主要功能，即调节性胞吐作用以及液体和电解质分泌。这一生理过程需要将两条信号通路组织成特定细胞结构域和紧密排列的复合物。这些结构域是由膜接触位点（MCS）形成的。本文综述了外分泌细胞中 Ca 信号转导的基本特性、MCS 在细胞信号转导的组织以及 Ca 和 cAMP 信号通路相互作用和协同中的作用，最后讨论了 Ca 和 cAMP 通路协同刺激上皮细胞液体和电解质分泌的机制。
