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ANOCTAMIN 的连接功能。

The tether function of the anoctamins.

机构信息

From the Epithelial Signaling and Transport Section, National Institute of Dental Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Cell Calcium. 2024 Jul;121:102875. doi: 10.1016/j.ceca.2024.102875. Epub 2024 Apr 20.

DOI:10.1016/j.ceca.2024.102875
PMID:38701708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11166512/
Abstract

The core functions of the anoctamins are Cl channel activity and phosphatidylserine (and perhaps other lipids) scrambling. These functions have been extensively studied in various tissues and cells. However, another function of the anoctamins that is less recognized and minimally explored is as tethers at membrane contact sites. This short review aims to examine evidence supporting the localization of the anoctamins at membrane contact sites, their tether properties, and their functions as tethers.

摘要

TMEM16 蛋白的核心功能为氯离子通道活性和磷脂酰丝氨酸（及其他脂质）翻转。这些功能已在各种组织和细胞中得到广泛研究。然而，TMEM16 蛋白的另一个功能则较少被认识和研究，即作为膜接触位点的连接蛋白。这篇简短的综述旨在探讨支持 TMEM16 蛋白定位于膜接触位点、连接蛋白特性及其作为连接蛋白功能的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f730/11166512/c31d2cdd4a9b/nihms-1991241-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f730/11166512/819a2013fd52/nihms-1991241-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f730/11166512/c31d2cdd4a9b/nihms-1991241-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f730/11166512/819a2013fd52/nihms-1991241-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f730/11166512/c31d2cdd4a9b/nihms-1991241-f0004.jpg

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