Kish S J, Schut L, Simmons J, Gilbert J, Chang L J, Rebbetoy M
Human Brain Laboratory, Clarke Institute of Psychiatry, Toronto, Canada.
J Neurol Neurosurg Psychiatry. 1988 Apr;51(4):544-8. doi: 10.1136/jnnp.51.4.544.
The activity was measured of the acetylcholine catabolising enzyme acetylcholinesterase (AChE) in brain after necropsy of seven patients from one established pedigree with dominantly-inherited olivopontocerebellar atrophy (OPCA), a cerebellar ataxia disorder in which neuropathological changes are assumed to be primarily restricted to cerebellum, lower brain stem and spinal cord. Mean AChE activity was significantly reduced in cerebral (-51% to 65%) and cerebellar (-47%) cortex with a less severe change (-37%) in the hippocampus. The magnitude of the enzyme reduction in cerebral cortex was equal to or greater than that reported in brain of demented Alzheimer's and Parkinson's disease patients having loss of AChE-containing nucleus basalis cholinergic neurons. It is concluded that the data provide additional biochemical evidence suggesting a cerebral cortical cholinergic denervation in OPCA.
对来自一个已确定的显性遗传橄榄体脑桥小脑萎缩（OPCA）家系的7名患者尸检后的大脑中乙酰胆碱分解酶乙酰胆碱酯酶（AChE）的活性进行了测量。OPCA是一种小脑共济失调疾病，其神经病理变化被认为主要局限于小脑、脑桥下部和脊髓。大脑皮层（-51%至65%）和小脑皮层（-47%）中的平均AChE活性显著降低，海马体中的变化较轻（-37%）。大脑皮层中酶减少的程度等于或大于患有含乙酰胆碱酯酶的基底核胆碱能神经元丧失的痴呆型阿尔茨海默病和帕金森病患者大脑中所报告的程度。得出的结论是，这些数据提供了额外的生化证据，表明OPCA中存在大脑皮层胆碱能去神经支配。
