[基于影像组学预测甲状腺乳头状癌患者颈部中央淋巴结转移]
[Radiomics for prediction of central lymph node metastasis in the neck in patients with thyroid papillary carcinoma].
作者信息
Wang Weizhen, Li Yingjia
机构信息
Department of Medical Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2019 Sep 30;39(9):1094-1098. doi: 10.12122/j.issn.1673-4254.2019.09.15.
OBJECTIVE
To explore the feasibility of radiomics for predicting lymph node metastasis in the central region of the neck in patients with thyroid papillary carcinoma (PTC).
METHODS
A total of 189 patients with PTC confirmed by thyroid fine needle aspiration biopsy were prospectively enrolled in this study. The cross-sectional and longitudinal ultrasound images and the images of both sections were analyzed for predicting central lymph node metastasis using a radiomics approach with pathological results as the gold standard.
RESULTS
In the 189 patients, the accuracy, sensitivity and specificity of preoperative thyroid ultrasonography for diagnosis of central lymph node metastasis was 69.39%, 64% and 73%, respectively. Based on the ultrasound images of the cross-sections, longitudinal sections and both sections, the accuracy, sensitivity and specificity of radiomics for predicting central lymph node metastasis was 66.06%/68.12%/77.69%, 53%/46%/40%, and 52%/53%/51%, respectively.
CONCLUSIONS
Radiomics with combined analysis of the ultrasound images on the cross-section and longitudinal section images achieves a higher accuracy for predicting central lymph node metastasis than analysis a single section, and its diagnostic accuracy is much higher than that of conventional ultrasound examination.
目的
探讨基于影像组学预测甲状腺乳头状癌（PTC）患者颈部中央区淋巴结转移的可行性。
方法
本研究前瞻性纳入189例经甲状腺细针穿刺活检确诊的PTC患者。以病理结果为金标准，采用影像组学方法对横断面及纵断面超声图像和双断面图像进行分析，以预测中央区淋巴结转移。
结果
189例患者中，术前甲状腺超声诊断中央区淋巴结转移的准确性、敏感性和特异性分别为69.39%、64%和73%。基于横断面、纵断面及双断面超声图像，影像组学预测中央区淋巴结转移的准确性、敏感性和特异性分别为66.06%/68.12%/77.69%、53%/46%/40%和52%/53%/51%。
结论
影像组学联合分析横断面和纵断面超声图像预测中央区淋巴结转移的准确性高于单断面分析，且其诊断准确性远高于传统超声检查。
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