镰状细胞病中非侵入性尿肾功能生物标志物：概述。
Non-invasive urinary biomarkers of renal function in sickle cell disease: an overview.
机构信息
Post-Graduation Program in Pharmaceutical Sciences, School of Pharmacy, Federal University of Ceara, Capitão Francisco Pedro, Street, n.1210 - Rodolfo Teófilo, Fortaleza, Ceara, CEP 60430-370, Brazil.
Medical Sciences Post-Graduation Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
出版信息
Ann Hematol. 2019 Dec;98(12):2653-2660. doi: 10.1007/s00277-019-03813-9. Epub 2019 Oct 23.
Sickle cell disease (SCD) is a hereditary condition characterized by homozygosis of the hemoglobin S (HbS) gene. Marked morbimortality is observed due to chronic hemolysis, endothelial injury, and episodes of vaso-occlusion, which leads to multi-organ damage. Renal impairment is common and may have different presentations, such as deficiency in urinary acidification or concentration, glomerulopathies, proteinuria, and hematuria, frequently resulting in end-stage renal disease (ESRD). Novel biomarkers of renal function, such as kidney injury molecule 1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) and monocyte chemoattractant protein 1 (MCP-1) are being studied in order to enable early diagnosis of kidney damage in SCD.
镰状细胞病（SCD）是一种遗传性疾病，其特征是血红蛋白 S（HbS）基因的纯合子。由于慢性溶血、内皮损伤和血管阻塞发作，导致多器官损伤，因此观察到明显的发病率和死亡率。肾脏损害很常见，可能有不同的表现，如尿酸化或浓缩功能缺陷、肾小球病变、蛋白尿和血尿，常导致终末期肾病（ESRD）。目前正在研究肾损伤分子 1（KIM-1）、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和单核细胞趋化蛋白 1（MCP-1）等新型肾功能生物标志物，以便能够早期诊断 SCD 中的肾脏损伤。
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