Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, People's Republic of China.
Psychoradiology Research Unit of Chinese Academy of Medical Sciences (2018RU011), West China Hospital of Sichuan University, Chengdu, 610041, People's Republic of China.
Eur Child Adolesc Psychiatry. 2020 Aug;29(8):1075-1087. doi: 10.1007/s00787-019-01421-6. Epub 2019 Oct 22.
Psychological resilience refers to the ability to adapt effectively in the face of adversity, which is closely related to an individual's psychological and physical health and well-being. Although previous behavioural studies have shown sex differences in psychological resilience, little is known about the neural basis of sex differences in psychological resilience. Here, we measured amplitude of low-frequency fluctuations (ALFF) via resting-state functional magnetic resonance imaging to investigate the sex-linked neurofunctional basis of psychological resilience in 231 healthy adolescents. At the behavioural level, we replicated previous findings indicating that males are more resilient than females. At the neural level, we found sex differences in the relationship between psychological resilience and ALFF in the right orbitofrontal cortex (OFC). Specifically, males showed a positive correlation between psychological resilience and ALFF in the right OFC, while females showed a negative correlation in this region. The sex-specific association between psychological resilience and spontaneous brain activity might be dependent on differences in hormonal systems and brain development between male and female adolescents. Taken together, the results of our study might provide the first evidence of sex-specific neurofunctional substrates of psychological resilience in adolescents, emphasizing the vital role of sex effects in future psychological resilience-related studies.
心理弹性是指个体在面对逆境时有效适应的能力，与个体的身心健康和幸福感密切相关。尽管先前的行为研究已经表明心理弹性存在性别差异，但对于心理弹性性别差异的神经基础知之甚少。在这里，我们通过静息态功能磁共振成像测量了低频振幅（ALFF），以研究 231 名健康青少年心理弹性的性别相关神经功能基础。在行为层面，我们复制了先前的发现，表明男性比女性更有弹性。在神经层面，我们发现心理弹性与右侧眶额皮层（OFC）的 ALFF 之间的关系存在性别差异。具体来说，男性的心理弹性与右侧 OFC 的 ALFF 呈正相关，而女性在该区域呈负相关。心理弹性与自发脑活动之间的这种性别特异性关联可能取决于男性和女性青少年之间激素系统和大脑发育的差异。总之，我们研究的结果可能为青少年心理弹性的性别特异性神经功能基础提供了首个证据，强调了在未来与心理弹性相关的研究中性别效应的重要作用。
