School of Psychology, Shaanxi Normal University, China.
Department of Psychology, Hunan Normal University, China.
Soc Cogn Affect Neurosci. 2018 Sep 4;13(7):755-763. doi: 10.1093/scan/nsy045.
Psychological resilience reflects the capacity to bounce back from stress, which plays an important role in health and well-being. However, less is known about the neural substrate for psychological resilience and the underlying mechanism for how psychological resilience enhances subjective well-being in the healthy brain. To investigate these issues, we employed fractional amplitude of low-frequency fluctuations (fALFF) measured with resting-state fMRI in 100 young healthy adults. The correlation analysis found that higher psychological resilience was related to lower fALFF in the left orbitofrontal cortex (OFC), which is involved in reward-related processing and emotion regulation. Furthermore, the mediation analysis indicated that psychological resilience acted as a full mediator of the association between the fALFF in left OFC and subjective well-being indicators (i.e. life satisfaction and hedonic balance). Importantly, these results remained significant after controlling for the effect of gray matter volume and regional homogeneity in the region. Overall, the present study provides the further evidence for functional neural substrates of psychological resilience and reveals a potential mechanism that psychological resilience mediates the effect of spontaneous brain activity on subjective well-being.
心理弹性反映了从压力中恢复的能力，它在健康和幸福感中起着重要作用。然而，对于心理弹性的神经基础以及心理弹性如何增强健康大脑中的主观幸福感的潜在机制，了解甚少。为了研究这些问题，我们采用静息态功能磁共振成像（rs-fMRI）测量的低频振幅分数（fALFF），对 100 名年轻健康成年人进行了研究。相关分析发现，较高的心理弹性与左眶额皮层（OFC）的 fALFF 降低有关，左 OFC 参与与奖励相关的处理和情绪调节。此外，中介分析表明，心理弹性是左 OFC 的 fALFF 与主观幸福感指标（即生活满意度和享乐平衡）之间关联的完全中介。重要的是，在控制了该区域的灰质体积和局部一致性的影响后，这些结果仍然具有统计学意义。总的来说，本研究为心理弹性的功能神经基础提供了进一步的证据，并揭示了心理弹性介导自发脑活动对主观幸福感影响的潜在机制。
