2nd Department of Ophthalmology, Medical School, Aristotle University of Thessaloniki, "Papageorgiou" Hospital, 56429, N.Efkarpia, Thessaloniki, Greece.
2nd Department of Neonatal Care Unit, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Int Ophthalmol. 2020 Feb;40(2):385-391. doi: 10.1007/s10792-019-01195-5. Epub 2019 Oct 22.
To assess the frequency of retinopathy of prematurity (ROP) and evaluate the appropriateness of screening guidelines in a tertiary hospital in Thessaloniki, Greece.
Retrospective review of consecutive infants admitted to the IInd Department of the Neonatal Care Unit of Aristotle University in the period April 2004-2015. ROP screening took place according to the Royal College of Paediatrics and Child Health and Royal College of Ophthalmologists (UK) guidelines [i.e. gestational age < 32 weeks and/or birth weight < 1501 g)], plus a few additional cases due to comorbidity.
1178 out of the 8782 admitted infants underwent ROP screening. ROP was detected in 232 (19.7%) infants of whom 87 developed severe form of the disease (i.e. ≥ stage 3). Treatment was required in 30 (2.5%) infants, all of whom fulfilled the screening criteria. Two of the 206 infants who were additionally screened due to comorbidity developed severe ROP which regressed spontaneously. Disease regression was achieved in 27/29 (93%) treated infants who survived.
The frequency of ROP observed in this cohort was as low as that reported in other developed countries. The currently used screening criteria permitted identification of all infants who were at risk and, therefore, need not be changed.
评估希腊塞萨洛尼基一家三级医院早产儿视网膜病变（ROP）的发病率，并评估筛查指南的适宜性。
回顾性分析 2004 年 4 月至 2015 年期间在亚里士多德大学新生儿护理部 II 区连续入院的婴儿。ROP 筛查按照皇家儿科学会和皇家眼科医师学院（英国）的指南进行[即胎龄<32 周和/或出生体重<1501 克]，此外还因合并症增加了少数几个病例。
在 8782 名入院婴儿中，有 1178 名接受了 ROP 筛查。在 232 名（19.7%）患有 ROP 的婴儿中，有 87 名患有严重形式的疾病（即≥第 3 期）。需要治疗的婴儿有 30 名（2.5%），他们都符合筛查标准。由于合并症而额外筛查的 206 名婴儿中有 2 名患有严重 ROP，且自行消退。存活的 27/29（93%）接受治疗的婴儿中，疾病得到了消退。
该队列中观察到的 ROP 发病率与其他发达国家报告的发病率一样低。目前使用的筛查标准能够识别所有处于危险中的婴儿，因此无需更改。
