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DJ-1 is dispensable for human stem cell homeostasis.

作者信息

Cheng Fang, Wang Si, Song Moshi, Liu Zunpeng, Liu Ping, Wang Lei, Wang Yanjiang, Zhao Qian, Yan Kaowen, Chan Piu, Zhang Weiqi, Qu Jing, Liu Guang-Hui

机构信息

National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.

University of Chinese Academy of Sciences, Beijing, 100049, China.

出版信息

Protein Cell. 2019 Nov;10(11):846-853. doi: 10.1007/s13238-019-00659-9.

DOI:10.1007/s13238-019-00659-9
PMID:31642032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6834734/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6834802/e719c61d54b3/13238_2019_659_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6834802/5e10ddbed9a7/13238_2019_659_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6834802/e719c61d54b3/13238_2019_659_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6834802/5e10ddbed9a7/13238_2019_659_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcc4/6834802/e719c61d54b3/13238_2019_659_Fig2a_HTML.jpg

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1
DJ-1 is dispensable for human stem cell homeostasis.DJ-1 对人类干细胞稳态并非不可或缺。
Protein Cell. 2019 Nov;10(11):846-853. doi: 10.1007/s13238-019-00659-9.
2
The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages.线粒体蛋白CHCHD2引发人类诱导多能干细胞向神经外胚层谱系的分化潜能。
J Cell Biol. 2016 Oct 24;215(2):187-202. doi: 10.1083/jcb.201601061. Epub 2016 Oct 17.
3
Inhibition of DJ-1 induces TFAM secretion from cancer cells to suppress tumor growth via promoting M1 macrophage polarization.
Cell Signal. 2025 Jul;131:111765. doi: 10.1016/j.cellsig.2025.111765. Epub 2025 Mar 25.
4
Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis.端粒依赖性和端粒非依赖性的 RAP1 在调节人类干细胞稳态中的作用。
Protein Cell. 2019 Sep;10(9):649-667. doi: 10.1007/s13238-019-0610-7. Epub 2019 Feb 22.
5
ETV5 is Essential for Neuronal Differentiation of Human Neural Progenitor Cells by Repressing NEUROG2 Expression.ETV5 通过抑制 NEUROG2 表达对于人神经祖细胞的神经元分化是必需的。
Stem Cell Rev Rep. 2019 Oct;15(5):703-716. doi: 10.1007/s12015-019-09904-4.
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Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells.线粒体呼吸调节人间充质干细胞的成脂分化。
PLoS One. 2013 Oct 18;8(10):e77077. doi: 10.1371/journal.pone.0077077. eCollection 2013.
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Low-Dose Methylmercury-Induced Genes Regulate Mitochondrial Biogenesis via miR-25 in Immortalized Human Embryonic Neural Progenitor Cells.低剂量甲基汞诱导的基因通过miR-25在永生化人胚胎神经祖细胞中调节线粒体生物合成。
Int J Mol Sci. 2016 Dec 9;17(12):2058. doi: 10.3390/ijms17122058.
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DJ-1 ameliorates ischemic cell death in vitro possibly via mitochondrial pathway.DJ-1 通过线粒体途径改善体外缺血细胞死亡。
Neurobiol Dis. 2014 Feb;62:56-61. doi: 10.1016/j.nbd.2013.09.007. Epub 2013 Sep 21.
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Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction.帕金森病相关 DJ-1 突变破坏线粒体动力学并导致线粒体功能障碍。
J Neurochem. 2012 Jun;121(5):830-9. doi: 10.1111/j.1471-4159.2012.07734.x. Epub 2012 Apr 12.
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The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering.帕金森病相关蛋白 DJ-1 通过增强内质网-线粒体连接来拮抗肿瘤抑制蛋白 p53 诱导的线粒体损伤。
Hum Mol Genet. 2013 Jun 1;22(11):2152-68. doi: 10.1093/hmg/ddt068. Epub 2013 Feb 14.

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Protocols for the application of human embryonic stem cell-derived neurons for aging modeling and gene manipulation.用于衰老建模和基因操作的人胚胎干细胞衍生神经元的应用方案。
STAR Protoc. 2025 Mar 21;6(1):103633. doi: 10.1016/j.xpro.2025.103633. Epub 2025 Feb 10.
2
CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism.CHCHD2突变小鼠表现出线粒体蛋白质积累和能量代谢紊乱。
bioRxiv. 2024 Aug 31:2024.08.30.610586. doi: 10.1101/2024.08.30.610586.
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Efficient preparation of high-purity and intact mesenchymal stem cell-derived extracellular vesicles.

本文引用的文献

1
The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease.DJ-1 的去糖基化酶活性减轻多巴胺能细胞中α-突触核蛋白的糖基化和聚集：氧化应激介导的 DJ-1 下调在帕金森病中的作用。
Free Radic Biol Med. 2019 May 1;135:28-37. doi: 10.1016/j.freeradbiomed.2019.02.014. Epub 2019 Feb 20.
2
Elevated expression of DJ-1 (encoded by the human PARK7 gene) protects neuronal cells from sevoflurane-induced neurotoxicity.DJ-1（由人类 PARK7 基因编码）的高表达可保护神经元细胞免受七氟醚诱导的神经毒性。
Cell Stress Chaperones. 2018 Sep;23(5):967-974. doi: 10.1007/s12192-018-0904-3. Epub 2018 May 4.
3
高效制备高纯度且完整的间充质干细胞衍生的细胞外囊泡。
Anal Bioanal Chem. 2024 Mar;416(8):1797-1808. doi: 10.1007/s00216-024-05193-0. Epub 2024 Feb 14.
4
Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H O release.降低氧化蛋白折叠可通过将 ER 到细胞核的 H O 释放最小化来减轻衰老。
EMBO Rep. 2023 Aug 3;24(8):e56439. doi: 10.15252/embr.202256439. Epub 2023 Jun 12.
5
SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing.SESN1 是 FOXO3 的效应因子，能抵抗人类骨骼肌衰老。
Cell Prolif. 2023 May;56(5):e13455. doi: 10.1111/cpr.13455. Epub 2023 May 17.
6
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner.人胚胎干细胞衍生的血管细胞以依赖 HIF-1α 的方式促进血管再生。
Protein Cell. 2024 Jan 3;15(1):36-51. doi: 10.1093/procel/pwad027.
7
BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates.BMAL1 兼职作为 LINE1 抑制和灵长类细胞衰老的守门员。
Nucleic Acids Res. 2022 Apr 8;50(6):3323-3347. doi: 10.1093/nar/gkac146.
8
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor.跨物种代谢组学分析确定尿苷为一种有效的促进再生因子。
Cell Discov. 2022 Feb 1;8(1):6. doi: 10.1038/s41421-021-00361-3.
9
Hyperthermia differentially affects specific human stem cells and their differentiated derivatives.热疗对特定人类干细胞及其分化衍生物有不同影响。
Protein Cell. 2022 Aug;13(8):615-622. doi: 10.1007/s13238-021-00887-y.
10
SIRT3 consolidates heterochromatin and counteracts senescence.SIRT3 巩固异染色质并抵抗衰老。
Nucleic Acids Res. 2021 May 7;49(8):4203-4219. doi: 10.1093/nar/gkab161.
Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
DJ-1 生理功能的最新研究发现：超越帕金森病。
Neurobiol Dis. 2017 Dec;108:65-72. doi: 10.1016/j.nbd.2017.08.005. Epub 2017 Aug 18.
4
Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.DJ-1/Park7 及其细菌同源物对鸟嘌呤糖基化的修复。
Science. 2017 Jul 14;357(6347):208-211. doi: 10.1126/science.aag1095. Epub 2017 Jun 8.
5
CHCHD2 is down-regulated in neuronal cells differentiated from iPS cells derived from patients with lissencephaly.在从无脑回畸形患者来源的诱导多能干细胞分化而来的神经细胞中，CHCHD2表达下调。
Genomics. 2015 Oct;106(4):196-203. doi: 10.1016/j.ygeno.2015.07.001. Epub 2015 Jul 15.
6
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.常染色体显性遗传晚发性帕金森病中 CHCHD2 突变：全基因组连锁和测序研究。
Lancet Neurol. 2015 Mar;14(3):274-82. doi: 10.1016/S1474-4422(14)70266-2. Epub 2015 Feb 4.
7
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.MNRR1（原名CHCHD2）是线粒体代谢的双细胞器调节因子。
Mitochondrion. 2015 Jan;20:43-51. doi: 10.1016/j.mito.2014.10.003. Epub 2014 Oct 12.
8
Stem cell aging: mechanisms, regulators and therapeutic opportunities.干细胞衰老：机制、调节因子和治疗机会。
Nat Med. 2014 Aug;20(8):870-80. doi: 10.1038/nm.3651.
9
Concealing cellular defects in pluripotent stem cells.隐瞒多能干细胞中的细胞缺陷。
Trends Cell Biol. 2013 Dec;23(12):587-92. doi: 10.1016/j.tcb.2013.07.001. Epub 2013 Aug 1.
10
DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders.DJ-1 与帕金森病和其他与年龄相关疾病的氧化应激预防。
Free Radic Biol Med. 2009 Nov 15;47(10):1354-61. doi: 10.1016/j.freeradbiomed.2009.08.003. Epub 2009 Aug 14.