Sonmez Ozge, Sonmez Mehmet
Istanbul University Cerrahpasa Medicine Faculty, English Medicine Programme, Istanbul, Turkey.
Karadeniz Technical University, School of Medicine, Department of Haematology, Trabzon, Turkey.
Porto Biomed J. 2017 Nov-Dec;2(6):311-314. doi: 10.1016/j.pbj.2017.05.005. Epub 2017 Oct 12.
Platelets have significant role in modulating clot formation. Additionally, emerging data indicates that platelets have considerable roles in inflammation and immune response. Platelets gather at the damaged cite and adhere to white blood cells. Subsequently, they release cytokines and chemokines which are chemotactic for neutrophils and monocytes. Therefore, platelets are necessary for targeting lymphocytes, neutrophils and monocytes to inflammation site. Those interactions enhance inflammation. Moreover, platelets serve as an immune cell by engulfing microbes. Presence of platelets affect prognosis in some bacterial or viral infection and several other diseases.
血小板在调节凝血形成过程中发挥着重要作用。此外，新出现的数据表明，血小板在炎症和免疫反应中也起着相当重要的作用。血小板聚集在受损部位并粘附于白细胞。随后，它们释放对中性粒细胞和单核细胞具有趋化作用的细胞因子和趋化因子。因此，血小板对于将淋巴细胞、中性粒细胞和单核细胞靶向炎症部位是必不可少的。这些相互作用会加剧炎症。此外，血小板通过吞噬微生物充当免疫细胞。血小板的存在会影响某些细菌或病毒感染以及其他几种疾病的预后。
