血小板在免疫系统和炎症中的作用。
Role of platelets in immune system and inflammation.
作者信息
Sonmez Ozge, Sonmez Mehmet
机构信息
Istanbul University Cerrahpasa Medicine Faculty, English Medicine Programme, Istanbul, Turkey.
Karadeniz Technical University, School of Medicine, Department of Haematology, Trabzon, Turkey.
出版信息
Porto Biomed J. 2017 Nov-Dec;2(6):311-314. doi: 10.1016/j.pbj.2017.05.005. Epub 2017 Oct 12.
Abstract
Platelets have significant role in modulating clot formation. Additionally, emerging data indicates that platelets have considerable roles in inflammation and immune response. Platelets gather at the damaged cite and adhere to white blood cells. Subsequently, they release cytokines and chemokines which are chemotactic for neutrophils and monocytes. Therefore, platelets are necessary for targeting lymphocytes, neutrophils and monocytes to inflammation site. Those interactions enhance inflammation. Moreover, platelets serve as an immune cell by engulfing microbes. Presence of platelets affect prognosis in some bacterial or viral infection and several other diseases.
摘要
血小板在调节凝血形成过程中发挥着重要作用。此外，新出现的数据表明，血小板在炎症和免疫反应中也起着相当重要的作用。血小板聚集在受损部位并粘附于白细胞。随后，它们释放对中性粒细胞和单核细胞具有趋化作用的细胞因子和趋化因子。因此，血小板对于将淋巴细胞、中性粒细胞和单核细胞靶向炎症部位是必不可少的。这些相互作用会加剧炎症。此外，血小板通过吞噬微生物充当免疫细胞。血小板的存在会影响某些细菌或病毒感染以及其他几种疾病的预后。
相似文献
1
Role of platelets in immune system and inflammation.
Porto Biomed J. 2017 Nov-Dec;2(6):311-314. doi: 10.1016/j.pbj.2017.05.005. Epub 2017 Oct 12.
2
Platelets: bridging hemostasis, inflammation, and immunity.
Int J Lab Hematol. 2013 Jun;35(3):254-61. doi: 10.1111/ijlh.12084.
3
Important roles of platelets as immune cells in the skin.
J Dermatol Sci. 2015 Feb;77(2):93-101. doi: 10.1016/j.jdermsci.2014.10.003. Epub 2014 Oct 18.
4
Neutrophils develop rapid proinflammatory response after engulfing Hb-activated platelets under intravascular hemolysis.
Clin Exp Immunol. 2019 Aug;197(2):131-140. doi: 10.1111/cei.13310. Epub 2019 May 27.
5
Development of pro-inflammatory phenotype in monocytes after engulfing Hb-activated platelets in hemolytic disorders.
Clin Immunol. 2017 Feb;175:133-142. doi: 10.1016/j.clim.2016.12.007. Epub 2016 Dec 28.
6
The prowess of platelets in immunity and inflammation.
Thromb Haemost. 2016 Sep 27;116(4):605-12. doi: 10.1160/TH16-04-0300. Epub 2016 Jul 7.
7
Emerging Roles for Platelets in Inflammation and Disease.
J Infect Dis Ther. 2014 Aug;2(4). doi: 10.4172/2332-0877.1000149. Epub 2014 Jun 24.
8
Essential roles for platelets during neutrophil-dependent or lymphocyte-mediated defense against bacterial pathogens.
Blood Coagul Fibrinolysis. 2016 Sep;27(6):667-72. doi: 10.1097/MBC.0000000000000455.
9
Platelet-neutrophil-interactions: linking hemostasis and inflammation.
Blood Rev. 2007 Mar;21(2):99-111. doi: 10.1016/j.blre.2006.06.001. Epub 2006 Sep 20.
10
Platelets--an important element of the immune system.
Pol J Vet Sci. 2013;16(2):407-13. doi: 10.2478/pjvs-2013-0058.
引用本文的文献
1
Genomic regions associated with bovine respiratory disease in pacific northwest Holstein cattle.
Front Vet Sci. 2025 Jul 31;12:1637087. doi: 10.3389/fvets.2025.1637087. eCollection 2025.
2
Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity Biomarkers.
Diagnostics (Basel). 2025 Jul 29;15(15):1905. doi: 10.3390/diagnostics15151905.
3
The unexplored relationship between spontaneous osteoclastogenesis and platelets in osteoporosis.
Front Med (Lausanne). 2025 Jul 21;12:1584022. doi: 10.3389/fmed.2025.1584022. eCollection 2025.
4
Platelets in Hepatocellular Carcinoma-From Pathogenesis to Targeted Therapy.
Cancers (Basel). 2025 Jul 18;17(14):2391. doi: 10.3390/cancers17142391.
5
Tumor Microenvironment, Inflammation, and Inflammatory Prognostic Indices in Diffuse Large B-Cell Lymphomas: A Narrative Review.
Int J Mol Sci. 2025 Jun 13;26(12):5670. doi: 10.3390/ijms26125670.
6
Effect of pilates on the physical and mental health of drug-dependent individuals - a randomized controlled trial.
BMC Psychiatry. 2025 Jun 2;25(1):559. doi: 10.1186/s12888-025-07008-7.
7
Use of hematological indices in severe septic acute kidney injury to predict hospital mortality and need for renal replacement therapy at discharge.
SAGE Open Med. 2025 May 15;13:20503121251333691. doi: 10.1177/20503121251333691. eCollection 2025.
8
Significant Associations Between Blood Cell Counts and Plasma Cytokines, Chemokines, and Growth Factors.
Int J Mol Sci. 2025 Apr 25;26(9):4065. doi: 10.3390/ijms26094065.
9
The emerging roles of platelet-derived extracellular vesicles in disease.
Ann Med. 2025 Dec;57(1):2499029. doi: 10.1080/07853890.2025.2499029. Epub 2025 May 3.
10
First Trimester Hematological Indices in Gestational Diabetes Mellitus: A Meta-Analysis.
J Endocr Soc. 2025 Mar 14;9(5):bvaf043. doi: 10.1210/jendso/bvaf043. eCollection 2025 May.
本文引用的文献
1
Relationship between activation and apoptosis in platelets.
Turk J Haematol. 2007 Dec 5;24(4):171-6.
2
Influence of Interleukin-1 Beta on Platelet-Poor Plasma Clot Formation: A Potential Impact on Early Bone Healing.
PLoS One. 2016 Feb 24;11(2):e0149775. doi: 10.1371/journal.pone.0149775. eCollection 2016.
3
Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
JAMA. 2016 Feb 23;315(8):762-74. doi: 10.1001/jama.2016.0288.
4
Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis.
Oncotarget. 2015 Dec 15;6(40):42733-48. doi: 10.18632/oncotarget.5811.
5
Platelets interact with Coxsackieviruses B and have a critical role in the pathogenesis of virus-induced myocarditis.
J Thromb Haemost. 2015 Feb;13(2):271-82. doi: 10.1111/jth.12782. Epub 2015 Jan 6.
6
Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis.
Blood. 2014 Jul 31;124(5):791-802. doi: 10.1182/blood-2013-11-536003. Epub 2014 Apr 22.
7
Emerging roles for platelets as immune and inflammatory cells.
Blood. 2014 May 1;123(18):2759-67. doi: 10.1182/blood-2013-11-462432. Epub 2014 Feb 28.
8
CLEC-2 is required for development and maintenance of lymph nodes.
Blood. 2014 May 15;123(20):3200-7. doi: 10.1182/blood-2013-03-489286. Epub 2014 Feb 14.
9
The multifaceted functions of neutrophils.
Annu Rev Pathol. 2014;9:181-218. doi: 10.1146/annurev-pathol-020712-164023. Epub 2013 Sep 16.
10
Platelets promote bacterial dissemination in a mouse model of streptococcal sepsis.
Microbes Infect. 2013 Sep-Oct;15(10-11):669-76. doi: 10.1016/j.micinf.2013.05.003. Epub 2013 May 25.
Zotero 插件