Department of Food Science, National Taiwan Ocean University, Keelung City, 202, Taiwan.
Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, 811, Taiwan.
Sci Rep. 2019 Oct 23;9(1):15233. doi: 10.1038/s41598-019-51821-6.
High blood glucose in diabetic patients often causes cardiovascular diseases (CVDs) that threats to human life. Curcumin (Cur) is known as an antioxidant agent, possesses anti-inflammatory activity, and prevents CVDs. However, the clinical application of curcumin was limited due to its low bioavailability. This study aimed to investigate the ameliorative effects of chitosan-encapsulated curcumin (CEC) on heart and kidney damages in streptozotocin-induced type-1 diabetes C57BL/6 mice model. The results showed that Cur- and CEC-treatments downregulated the blood sugar and total cholesterol level as well as enhanced insulin secretion. However, blood pressure, triglycerides content, and very low-density lipoprotein-cholesterol content were not changed. Histochemistry analysis revealed that both curcumin and chitosan-encapsulated curcumin ameliorated cell hypertrophy and nucleus enlargement in the left ventricular of heart and reduced fibrosis in the kidney, especially after the chitosan-encapsulated curcumin treatment. Our study suggested that chitosan can effectively enhance the protective effect of curcumin on the heart and kidney damages in type-1 diabetes mice model.
糖尿病患者的高血糖常导致心血管疾病（CVDs），威胁人类生命。姜黄素（Cur）作为一种抗氧化剂，具有抗炎活性，可预防 CVDs。然而，由于其生物利用度低，姜黄素的临床应用受到限制。本研究旨在探讨壳聚糖包封姜黄素（CEC）对链脲佐菌素诱导的 1 型糖尿病 C57BL/6 小鼠模型心脏和肾脏损伤的改善作用。结果表明，Cur 和 CEC 治疗可降低血糖和总胆固醇水平，并增强胰岛素分泌。然而，血压、甘油三酯含量和极低密度脂蛋白胆固醇含量没有变化。组织化学分析表明，姜黄素和壳聚糖包封姜黄素均可改善心脏左心室细胞肥大和细胞核增大，并减少肾脏纤维化，尤其是在壳聚糖包封姜黄素治疗后。我们的研究表明，壳聚糖可以有效增强姜黄素对 1 型糖尿病小鼠模型心脏和肾脏损伤的保护作用。
