Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
Biotech Research & Innovation Center, University of Copenhagen, Copenhagen, Denmark.
Adv Exp Med Biol. 2020;1131:1079-1102. doi: 10.1007/978-3-030-12457-1_43.
In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.
在多细胞生物中，细胞被持久的、动态的细胞外基质（ECM）所包围，它是动物体内最大的钙库。ECM 调节细胞行为的多个方面，包括细胞迁移和黏附、存活、基因表达和分化，因此在健康和疾病中发挥着重要作用。据报道，钙在 ECM 的组装中很重要，它与许多 ECM 蛋白结合。作为钙库，ECM 大分子可以直接与细胞表面受体相互作用，导致钙跨膜转运。本章主要集中讨论细胞-ECM 相互作用在细胞钙调节中的作用，以及钙本身如何介导这些相互作用。
