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水刀钻孔微骨折术治疗山羊距骨软骨缺损模型的安全性可行性研究

Feasibility Study to Determine if Microfracture Surgery Using Water Jet Drilling Is Potentially Safe for Talar Chondral Defects in a Caprine Model.

机构信息

Department of Orthopaedic Surgery, Amsterdam Academic Medical Centre, University of Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.

Department of BioMechanical Engineering, Delft University of Technology, Delft, Netherlands.

出版信息

Cartilage. 2021 Dec;13(2_suppl):1627S-1636S. doi: 10.1177/1947603519880332. Epub 2019 Oct 24.

Abstract

OBJECTIVE

Surgical microfracture is considered a first-line treatment for talar osteochondral defects. However, current rigid awls and drills limit access to all locations in human joints and increase risk of heat necrosis of bone. Using a flexible water jet instrument to drill holes can improve the reachability of the defect without inducing thermal damage. The aim of this feasibility study is to determine whether water jet drilling is potentially safe compared with conventional microfracture awls by studying side effects and perioperative complications, as well as the quality of cartilage repair tissue.

DESIGN

Talar chondral defects with 6-mm diameter were created bilaterally in 6 goats (12 samples). One defect in each goat was treated with microfracture created with conventional awls, the contralateral defect was treated with holes created with 5-second water jet bursts at a pressure of 50 MPa. Postoperative complications were recorded and after 24 weeks analyses were performed using the ICRS (International Cartilage Repair Society) macroscopic score and modified O'Driscoll histological score.

RESULTS

Several practical issues using the water jet in the operating theatre were noted. Water jet drilling resulted in fibrocartilage repair tissue similar to the repair tissue from conventional awls.

CONCLUSIONS

These results suggest that water jet drilling gives adequate fibrocartilage repair tissue. Furthermore, the results highlight essential prerequisites for safe application of surgical water jet drilling: stable water pressure, water jet beam coherence, stable positioning of the nozzle head when jetting, and minimizing excessive fluid extravasation.

摘要

目的

外科微骨折被认为是治疗距骨骨软骨缺损的一线治疗方法。然而,目前的刚性骨钻和钻头限制了进入人体关节所有部位的能力,并增加了骨热坏死的风险。使用柔性水射流仪器钻孔可以提高缺陷的可达性,而不会引起热损伤。本可行性研究的目的是通过研究副作用和围手术期并发症以及软骨修复组织的质量,确定与传统微骨折骨钻相比,水射流钻孔是否具有潜在的安全性。

设计

在 6 只山羊(12 个样本)中双侧创建直径为 6mm 的距骨软骨缺损。每只山羊的一个缺损用传统骨钻制成的微骨折治疗,对侧缺损用 50MPa 压力下的 5 秒水射流爆发制成的孔治疗。记录术后并发症,24 周后采用 ICRS(国际软骨修复学会)宏观评分和改良 O'Driscoll 组织学评分进行分析。

结果

在手术室使用水射流时注意到了几个实际问题。水射流钻孔导致纤维软骨修复组织类似于传统骨钻的修复组织。

结论

这些结果表明水射流钻孔可提供足够的纤维软骨修复组织。此外,这些结果突出了安全应用外科水射流钻孔的基本前提:稳定的水压、水射流束相干性、射流时喷嘴头的稳定定位以及最小化过多的流体渗出。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8376/8804798/955228960310/10.1177_1947603519880332-fig1.jpg

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