Prieto-Centurion Valentin, Casaburi Richard, Coultas David B, Kansal Mayank M, Kitsiou Spyros, Luo Julia J, Ma Jun, Rand Cynthia S, Tan Ai-Yui M, Krishnan Jerry A
University of Illinois at Chicago.
Los Angeles Biomedical Research Institute at Harbor-University of California-Los Angeles Medical Center, Torrance.
Chronic Obstr Pulm Dis. 2019 Oct 23;6(4):332-40. doi: 10.15326/jcopdf.6.4.2019.0136.
Low physical activity in patients with chronic obstructive pulmonary disease (COPD) is associated with increased morbidity and mortality. To inform the design of a home-based physical activity promotion program for patients with COPD recently discharged from a minority-serving hospital, we conducted a cohort study to evaluate objectively measured daily physical activity and patient-reported outcomes.
This was a 12-week prospective cohort study of patients with a physician diagnosis of COPD recently hospitalized (≤ 12 weeks) for respiratory symptoms. Daily physical activity was recorded using wrist-based and "clip-on" pedometers, and analyzed as mean daily step counts averaged over 7 days.
Twenty-two patients were enrolled a median (interquartile range, [IQR]) of 14 (7 to 29) days after hospital discharge. The median daily step count (IQR) in the first week after enrollment (week 1) was 3710 (1565 to 5129) steps. The median within-person change in daily step count (IQR) from week 1 to week 12 was 314 (-30 to 858) steps (=0.28). Within-person correlation of week-to-week daily step counts was high (r ≥ 0.75). Time from hospital discharge to enrollment was not correlated with mean daily step counts on week 1 (r= -0.13) and only weakly correlated with change in mean daily step counts from week 1 to week 12 (r=0.37).
Daily physical activity was variable in this cohort of recently hospitalized patients with COPD, but with little within-person change over a 12-week period. These observations highlight the need for flexible physical activity promotion programs addressing the needs of a heterogeneous patient population.
慢性阻塞性肺疾病(COPD)患者身体活动水平低与发病率和死亡率增加相关。为了为一家为少数族裔服务的医院近期出院的COPD患者设计一项居家身体活动促进计划提供信息,我们开展了一项队列研究,以评估客观测量的每日身体活动及患者报告的结局。
这是一项针对因呼吸道症状近期住院(≤12周)且经医生诊断为COPD的患者进行的为期12周的前瞻性队列研究。使用腕式和“夹式”计步器记录每日身体活动,并将其分析为7天平均每日步数。
22例患者在出院后中位数(四分位间距,[IQR])为14(7至29)天入组。入组后第一周(第1周)的中位数每日步数(IQR)为3710(1565至5129)步。从第1周到第12周,每日步数的个体内中位数变化(IQR)为314(-30至858)步(=0.28)。每周每日步数的个体内相关性较高(r≥0.75)。从出院到入组的时间与第1周的平均每日步数无相关性(r = -0.13),与第1周到第12周平均每日步数的变化仅呈弱相关性(r = 0.37)。
在这组近期住院的COPD患者中,每日身体活动存在差异,但在12周内个体内变化较小。这些观察结果凸显了需要有灵活的身体活动促进计划来满足异质性患者群体的需求。