壳聚糖和鞣酸基薄膜对正常细胞和癌细胞的响应。
Normal and cancer cells response on the thin films based on chitosan and tannic acid.
机构信息
Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, Nicolaus Copernicus University in Toruń, Gagarin 7, 87-100 Toruń, Poland.
Department of Cell Biology and Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Kraków, Poland.
出版信息
Toxicol In Vitro. 2020 Feb;62:104688. doi: 10.1016/j.tiv.2019.104688. Epub 2019 Oct 21.
A novel aspect of tissue engineering is the material selective influence on the different cell types. The cell viability is a parameter which determine the cell ability to proliferate in the contact with material. In the experimental study the thin films based on chitosan and tannic acid mixture in ratio 80/20, 50/50 and 20/80 were tested. The surface roughness decreases with increasing tannic acid content. The cell culture was established on the proposed films. In vitro tests were carried out for the different cell lines as MNT-1, SK-MEL-28, Saos-2, HaCaT and BMSC. The result showed the dependence on the material influence on the various cell lines.
组织工程学的一个新方面是材料对不同细胞类型的选择性影响。细胞活力是一个参数，它决定了细胞在与材料接触时增殖的能力。在实验研究中，测试了壳聚糖和单宁酸混合物比例为 80/20、50/50 和 20/80 的薄膜。随着单宁酸含量的增加，表面粗糙度降低。在提出的薄膜上建立了细胞培养。对不同的细胞系如 MNT-1、SK-MEL-28、Saos-2、HaCaT 和 BMSC 进行了体外测试。结果表明，材料对各种细胞系的影响是依赖的。
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