Kaczmarek-Szczepańska Beata, Sosik Adrianna, Małkowska Anna, Zasada Lidia, Michalska-Sionkowska Marta
Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland.
Department of Environmental Microbiology and Biotechnology, Faculty of Biology and Veterinary Science, Nicolaus Copernicus University in Toruń, 87-100 Torun, Poland.
Materials (Basel). 2021 Aug 28;14(17):4905. doi: 10.3390/ma14174905.
In this study, sodium alginate-based thin films were modified by the addition of tannic acid. Materials were obtained by solvent evaporation. They were characterized by the observation of its morphology and its surface by scanning electron microscope and atomic force microscope. The thermal properties were studied by differential scanning calorimetry. The concentration of tannic acid released from the material was determined by the Folin-Ciocalteu method. The material safety for biomedical application was determined by the hemolysis rate study in contact with sheep blood as well as platelet adhesion to the material surface. Based on the obtained results, we assume that proposed films based on sodium alginate/tannic acid are safe and may potentially find application in medicine.
在本研究中，通过添加单宁酸对海藻酸钠基薄膜进行了改性。材料通过溶剂蒸发获得。通过扫描电子显微镜和原子力显微镜观察其形态和表面对其进行表征。通过差示扫描量热法研究热性能。用福林-酚法测定材料释放的单宁酸浓度。通过与绵羊血液接触的溶血率研究以及血小板在材料表面的黏附情况来确定生物医学应用的材料安全性。基于所得结果，我们认为所提出的基于海藻酸钠/单宁酸的薄膜是安全的，并且可能在医学中找到应用。
