The Molecular Genetics Research Team, Department of Pharmaceutical Biology, Faculty of Pharmacy andBiotechnology, German University in Cairo, Cairo 12622, Egypt.
Pharmaceutical Technology Department, National Research Centre, Cairo 12622, Egypt.
Molecules. 2021 Mar 9;26(5):1486. doi: 10.3390/molecules26051486.
Tannic acid is a chief gallo-tannin belonging to the hydrolysable tannins extracted from gall nuts and other plant sources. A myriad of pharmaceutical and biological applications in the medical field has been well recognized to tannic acid. Among these effects, potential anticancer activities against several solid malignancies such as liver, breast, lung, pancreatic, colorectal and ovarian cancers have been reported. Tannic acid was found to play a maestro-role in tuning several oncological signaling pathways including JAK/STAT, RAS/RAF/mTOR, TGF-β1/TGF-β1R axis, VEGF/VEGFR and CXCL12/CXCR4 axes. The combinational beneficial effects of tannic acid with other conventional chemotherapeutic drugs have been clearly demonstrated in literature such as a synergistic anticancer effect and enhancement of the chemo-sensitivity in several resistant cases. Yet, clinical applications of tannic acid have been limited owing to its poor lipid solubility, low bioavailability, off-taste, and short half-life. To overcome such obstacles, novel drug delivery systems have been employed to deliver tannic acid with the aim of improving its applications and/or efficacy against cancer cells. Among these drug delivery systems are several types of organic and metallic nanoparticles. In this review, the authors focus on the molecular mechanisms of tannic acid in tuning several neoplastic diseases as well as novel drug delivery systems that can be used for its clinical applications with an attempt to provide a systemic reference to promote the development of tannic acid as a cheap drug and/or drug delivery system in cancer management.
鞣酸是一种主要的棓单宁，属于可水解单宁，从五倍子和其他植物来源中提取。鞣酸在医学领域有许多药物和生物学应用已得到广泛认可。在这些作用中，已经报道了鞣酸对几种实体恶性肿瘤如肝癌、乳腺癌、肺癌、胰腺癌、结直肠癌和卵巢癌具有潜在的抗癌活性。研究发现，鞣酸在调节几种肿瘤信号通路中发挥着重要作用，包括 JAK/STAT、RAS/RAF/mTOR、TGF-β1/TGF-β1R 轴、VEGF/VEGFR 和 CXCL12/CXCR4 轴。文献中清楚地表明，鞣酸与其他常规化疗药物联合使用具有协同抗癌作用，并增强了几种耐药病例的化疗敏感性。然而，由于鞣酸的脂溶性差、生物利用度低、口感不佳和半衰期短，其临床应用受到限制。为了克服这些障碍，已经采用了新型药物传递系统来递送鞣酸，目的是提高其在癌症细胞中的应用和/或疗效。这些药物传递系统包括几种类型的有机和金属纳米粒子。在这篇综述中，作者重点介绍了鞣酸在调节几种肿瘤性疾病中的分子机制，以及可用于其临床应用的新型药物传递系统，试图为促进鞣酸作为一种廉价药物和/或癌症治疗中的药物传递系统的发展提供系统的参考。
