Bai Fan, Zheng Wen, Dong Yan, Wang Juan, Garstka Malgorzata A, Li Ruilian, An Jingang, Ma Huiqun
The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Oncotarget. 2017 Nov 1;9(1):1266-1278. doi: 10.18632/oncotarget.22260. eCollection 2018 Jan 2.
To evaluate the association of serum levels of adipokines and cytokines with psoriasis.
A comprehensive literature search was performed in PubMed, ScienceDirect and Web of Science for the available relevant studies published before December 1, 2016. Differences in serum marker levels between patients and controls were pooled as standardized mean differences (SMDs) with 95% confidence interval to combine the effect estimations. We also conducted stratified analysis, meta-regression analysis and sensitivity analysis.
Sixty-three studies containing 2876 psoriasis patients and 2237 healthy controls were included in this meta-analysis. The pooled serum levels of TNF-α, IFN-γ, IL-2, IL-6, IL-8, IL-18, IL-22, chemerin, lipocalin-2, resistin, sE-selectin, fibrinogen and C3 were higher in psoriasis patients compared with healthy controls (all < 0.05). In contrast, adiponectin levels were lower. Serum levels of IL-1β, IL-4, IL-10, IL-12, IL-17, IL-21, IL-23, visfatin and omentin were not significantly different between psoriasis patients and controls (all > 0.05). However, increased serum levels of IL-17 correlated with psoriasis in men. For other biomarkers, age, gender and psoriasis area and severity index did not explain the differences in effect size between the studies.
Serum levels of TNF-α, IFN-γ, IL-2, IL-6, IL-8, IL-18, IL-22, chemerin, lipocalin-2, resistin, sE-selectin, fibrinogen, complement 3, and adiponectin correlate with psoriasis and can be used as potential biomarkers for psoriasis and response to the treatment. Future studies are needed to identify additional players involved in the pathogenesis of psoriasis and to fully decipher the underlying mechanism.
评估血清中脂肪因子和细胞因子水平与银屑病的相关性。
在PubMed、ScienceDirect和Web of Science数据库中进行全面的文献检索，查找2016年12月1日前发表的相关研究。将患者与对照组血清标志物水平的差异合并为标准化均数差（SMD）及95%置信区间，以合并效应估计值。我们还进行了分层分析、Meta回归分析和敏感性分析。
本Meta分析纳入了63项研究，共2876例银屑病患者和2237例健康对照。与健康对照相比，银屑病患者血清中TNF-α、IFN-γ、IL-2、IL-6、IL-8、IL-18、IL-22、趋化素、lipocalin-2、抵抗素、可溶性E选择素、纤维蛋白原和C3的合并水平更高（均P<0.05）。相比之下，脂联素水平较低。银屑病患者与对照组血清中IL-1β、IL-4、IL-10、IL-12、IL-17、IL-21、IL-23、内脂素和网膜素水平无显著差异（均P>0.05）。然而，男性血清IL-17水平升高与银屑病相关。对于其他生物标志物，年龄、性别以及银屑病面积和严重程度指数并不能解释各研究间效应大小的差异。
血清中TNF-α、IFN-γ、IL-2、IL-6、IL-8、IL-18、IL-22、趋化素、lipocalin-2、抵抗素、可溶性E选择素、纤维蛋白原、补体3和脂联素水平与银屑病相关，可作为银屑病及治疗反应的潜在生物标志物。未来需要进一步研究以确定银屑病发病机制中涉及的其他因素，并全面解读其潜在机制。
