Division of Mental and Physical Health, Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, PO Box 222 Skøyen, N-0213, Oslo, Norway.
Faculty of Medicine, University of Oslo, Oslo, Norway.
Osteoporos Int. 2020 Jan;31(1):131-140. doi: 10.1007/s00198-019-05191-4. Epub 2019 Oct 25.
In 50-79-year-olds who participated in the Tromsø Study (1994-1995), the risk of non-vertebral osteoporotic fractures during 15 years follow-up increased by 22% in men and 9% in women per 1 SD lower grip strength. The strongest association was observed in men aged 50-64 years.
We aimed to explore whether low grip strength was associated with increased risk of non-vertebral osteoporotic fracture in the population-based Tromsø Study 1994-1995.
Grip strength (bar) was measured by a Martin Vigorimeter and fractures were retrieved from the X-ray archives at the University Hospital of North Norway between 1994 and 2010. At baseline, weight and height were measured, whereas information on the other covariates were obtained through self-reported questionnaires. Cox regression was used to estimate the hazard ratio (HR) of fracture in age- and gender-specific quintiles of grip-strength, and per 1 SD lower grip strength. Similar analyses were done solely for hip fractures. Adjustments were made for age, height, body mass index (BMI), marital status, education, smoking, physical activity, use of alcohol, self-perceived health, and self-reported diseases.
In 2891 men and 4002 women aged 50-79 years, 1099 non-vertebral osteoporotic fractures-including 393 hip fractures-were sustained during the median 15 years follow-up. Risk of non-vertebral osteoporotic fracture increased with declining grip strength: hazard ratios per SD decline was 1.22 (95% CI 1.05-1.43) in men and 1.09 (95% CI 1.01-1.18) in women. HR for fracture in lower vs. upper quintile was 1.58 (95% CI 1.02-2.45) in men and 1.28 (95% CI 1.03-1.59) in women. The association was most pronounced in men aged 50-64 years with HR = 3.39 (95% CI 1.76-6.53) in the lower compared to the upper quintile.
The risk of non-vertebral osteoporotic fracture increased with declining grip-strength in both genders, particularly in men aged 50-64 years.
在参与特罗姆瑟研究（1994-1995 年）的 50-79 岁人群中，男性握力每降低 1 标准差，非椎体骨质疏松性骨折的风险在 15 年随访期间增加 22%，女性增加 9%。在 50-64 岁的男性中，观察到的相关性最强。
我们旨在探讨在基于人群的特罗姆瑟研究 1994-1995 年中，握力较低是否与非椎体骨质疏松性骨折风险增加有关。
握力（棒）通过 Martin Vigorimeter 测量，骨折通过在北挪威大学医院的 X 射线档案中检索，时间范围为 1994 年至 2010 年。在基线时，测量体重和身高，而其他协变量的信息则通过自我报告的问卷获得。使用 Cox 回归估计按年龄和性别分组的握力五分位数的骨折风险比（HR），以及每降低 1 标准差的握力。仅对髋部骨折进行了类似的分析。调整了年龄、身高、体重指数（BMI）、婚姻状况、教育程度、吸烟、身体活动、饮酒、自我感知健康状况和自我报告的疾病。
在 2891 名 50-79 岁的男性和 4002 名女性中，在中位数为 15 年的随访期间，共发生 1099 例非椎体骨质疏松性骨折，包括 393 例髋部骨折。随着握力下降，非椎体骨质疏松性骨折的风险增加：男性每降低 1 标准差的 HR 为 1.22（95%CI 1.05-1.43），女性为 1.09（95%CI 1.01-1.18）。与第 5 quintile 相比，第 1 quintile 的骨折 HR 为 1.58（95%CI 1.02-2.45），女性为 1.28（95%CI 1.03-1.59）。在 50-64 岁的男性中，这种相关性最为显著，第 5 quintile 的 HR 为 3.39（95%CI 1.76-6.53）。
在两性中，握力下降与非椎体骨质疏松性骨折风险增加相关，尤其是在 50-64 岁的男性中。
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