Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York.
JAMA Netw Open. 2019 Oct 2;2(10):e1914031. doi: 10.1001/jamanetworkopen.2019.14031.
Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States, and oral HPV infection is associated with increased risk of oropharyngeal cancer.
To describe the risk factors for oral HPV in sexually active female adolescents receiving the quadrivalent vaccine.
DESIGN, SETTING, AND PARTICIPANTS: Longitudinal cohort study involving repeated collection of oral rinse specimens from sexually active female adolescents conducted between October 19, 2007, and March 9, 2017, at a large adolescent health center in New York, New York, that provides free health care, including HPV vaccination.
Human papillomavirus vaccination and self-reported history of sexual behavior.
Prevalence of HPV in the oral cavity.
Among the 1259 participants who were included in this study, median age at entry into the study was 18 (range, 13-21) years; 638 (50.7%) were of African American descent, 569 (45.2%) were of Hispanic descent, 43 (3.4%) reported another race/ethnicity, and race/ethnicity was unspecified for 9 (0.7%). The median (mode) age at first sexual activity was 14.8 (14) years, and 1161 (92.2%) reported having had oral sex. Human papillomavirus DNA was detected in baseline oral rinse samples of 78 of the 1259 participants (6.2%; 95% CI, 4.9%-7.6%). There was a significant decrease in oral HPV detection with time (in years) since first engaging in sexual activities, independent of age and concurrent detection of cervical HPV; comparing 4 or more years with 1 year or less, the odds ratio was 0.45 (95% CI, 0.21-0.96). Detection of vaccine types (HPV-6, HPV-11, HPV-16, and HPV-18) was significantly lower among participants who had received at least 1 dose of the quadrivalent HPV vaccine at the time of enrollment compared with those who were unvaccinated (odds ratio, 0.20; 95% CI, 0.04-0.998).
This study's findings suggest that detection of HPV in the oral cavity is not uncommon in sexually active female adolescents. In addition, HPV vaccination is associated with a significant decrease in detection of HPV vaccine types in the oral cavity.
人乳头瘤病毒（HPV）是美国最常见的性传播感染，口腔 HPV 感染与口咽癌风险增加相关。
描述接受四价疫苗的性活跃女性青少年中口腔 HPV 的风险因素。
设计、地点和参与者：这是一项纵向队列研究，在纽约市的一家大型青少年健康中心重复采集性活跃的女性青少年的口腔冲洗样本，该中心提供免费医疗保健，包括 HPV 疫苗接种。研究于 2007 年 10 月 19 日至 2017 年 3 月 9 日进行。
HPV 疫苗接种和自我报告的性行为史。
口腔 HPV 的流行率。
在这项研究中，纳入了 1259 名参与者，入组时的中位年龄为 18 岁（范围，13-21 岁）；638 名（50.7%）为非裔美国人，569 名（45.2%）为西班牙裔，43 名（3.4%）报告了其他种族/民族，9 名（0.7%）的种族/民族未指定。首次性行为的中位（模态）年龄为 14.8 岁（14 岁），1161 名（92.2%）报告有过口交。在 1259 名参与者的基线口腔冲洗样本中，有 78 名（6.2%；95%CI，4.9%-7.6%）检测到 HPV DNA。自首次发生性行为以来，口腔 HPV 的检测随时间（年）呈显著下降，独立于年龄和同期宫颈 HPV 的检测；与 4 年或以上相比，1 年或以下的比值比为 0.45（95%CI，0.21-0.96）。与未接种疫苗者相比，在入组时已至少接种一剂四价 HPV 疫苗的参与者中，疫苗型 HPV（HPV-6、HPV-11、HPV-16 和 HPV-18）的检测率显著降低（比值比，0.20；95%CI，0.04-0.998）。
本研究结果表明，性活跃的女性青少年口腔 HPV 的检测并不少见。此外，HPV 疫苗接种与口腔 HPV 疫苗型检测显著降低相关。
