Ogaard B, Rølla G, Arends J, ten Cate J M
Department of Orthodontics, Dental Faculty, University of Oslo, Norway.
Am J Orthod Dentofacial Orthop. 1988 Aug;94(2):123-8. doi: 10.1016/0889-5406(88)90360-5.
Clinical experiments were performed to investigate the effect of fluoride on carious lesion development and on lesions established during fixed orthodontic therapy. All presently available fluoride agents are developed from the concept of fluoridating the enamel in the form of fluorhydroxyapatite. Recent research has indicated, however, that calcium fluoride formation may be a major aspect of the mechanism of the cariostatic effect of topical fluoride. Therefore a fluoride solution with very low pH (1.9) that induced large amounts of calcium fluoride also was tested on lesion development underneath orthodontic bands. Daily fluoride mouth rinsing with a 0.2% solution sodium fluoride (NaF) retarded lesion development significantly, whereas the fluoride solution with low pH inhibited lesion formation completely. Fluoride applied as a mouth rinse to plaque-covered lesions underneath orthodontic bands retarded lesion progression. The remineralizing capacity of saliva was found to be rapid in the absence of any fluoride. Although white spot lesions may remineralize and even disappear, most of the emphasis should be directed against prevention of carious lesion development during treatment with fixed orthodontic appliances.
进行了临床实验以研究氟化物对龋损发展以及固定正畸治疗期间已形成龋损的影响。目前所有可用的氟化物制剂都是基于以氟羟磷灰石形式使牙釉质氟化的概念开发的。然而,最近的研究表明,氟化钙的形成可能是局部用氟化物防龋作用机制的一个主要方面。因此,一种pH值非常低(1.9)且能诱导大量氟化钙形成的氟化物溶液也被用于测试正畸带环下方龋损的发展情况。每天用0.2%的氟化钠(NaF)溶液进行氟化物漱口水冲洗可显著延缓龋损发展,而低pH值的氟化物溶液则能完全抑制龋损形成。将氟化物作为漱口水应用于正畸带环下方被菌斑覆盖的龋损可延缓龋损进展。发现在没有任何氟化物的情况下,唾液的再矿化能力很快。尽管白斑龋损可能会再矿化甚至消失,但大多数重点应放在预防固定正畸矫治器治疗期间龋损的发展上。