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在脑部CT扫描上，甲氨蝶呤性白质脑病酷似脑脓肿。

Methotrexate leukoencephalopathy mimicking cerebral abscess on CT brain scan.

作者信息

Poskitt K J, Steinbok P, Flodmark O

机构信息

Department of Radiology, University of British Columbia, Vancouver, Canada.

出版信息

Childs Nerv Syst. 1988 Apr;4(2):119-21. doi: 10.1007/BF00271394.

DOI:10.1007/BF00271394
PMID:3165306
Abstract

A case is reported of methotrexate leukoencephalopathy presenting as an intracerebral rim-enhancing mass lesion of CT scan. The implications of this rare presentation of methotrexate leukoencephalopathy for therapy are discussed.

摘要

报告了一例甲氨蝶呤白质脑病，其在CT扫描中表现为脑内环形强化肿块病变。讨论了甲氨蝶呤白质脑病这种罕见表现对治疗的影响。

相似文献

1
Methotrexate leukoencephalopathy mimicking cerebral abscess on CT brain scan.在脑部CT扫描上，甲氨蝶呤性白质脑病酷似脑脓肿。
Childs Nerv Syst. 1988 Apr;4(2):119-21. doi: 10.1007/BF00271394.
2
Computed tomographic appearance of methotrexate-induced necrotizing leukoencephalopathy.甲氨蝶呤所致坏死性白质脑病的计算机断层扫描表现。
Radiology. 1977 Feb;122(2):377-8. doi: 10.1148/122.2.377.
3
[Cerebral complications after irradiation and administration of methotrexate in lymphatic leukemia in the computerized tomography picture].[计算机断层扫描图像中淋巴细胞白血病患者接受放疗和甲氨蝶呤治疗后的脑部并发症]
Cesk Neurol Neurochir. 1984 May;47(3):158-63.
4
Computer assisted tomography in methotrexate encephalopathy.甲氨蝶呤脑病的计算机辅助断层扫描
J Comput Assist Tomogr. 1977 Apr;1(2):216-21. doi: 10.1097/00004728-197704000-00011.
5
Treatment-related leukoencephalopathy. A study of three cases and literature review.
Medicine (Baltimore). 1986 May;65(3):154-62.
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[Disseminated necrotizing leukoencephalopathy following intrathecal methotrexate in childhood leukemia (author's transl)].
Fukuoka Igaku Zasshi. 1976 Jan;67(1):24-31.
7
Computed tomography brain scans in children with acute lymphocytic leukemia receiving methotrexate alone as central nervous system prophylaxis.接受甲氨蝶呤单药作为中枢神经系统预防治疗的急性淋巴细胞白血病患儿的脑部计算机断层扫描。
Cancer. 1980 May 1;45(9):2274-8. doi: 10.1002/1097-0142(19800501)45:9<2274::aid-cncr2820450909>3.0.co;2-6.
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Methotrexate-induced leukoencephalopathy. A case report.
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[Intracerebral calcifications associated with intrathecal methotrexate therapy in acute lymphocytic leukemia (author's transl)].急性淋巴细胞白血病鞘内注射甲氨蝶呤治疗相关的脑内钙化（作者译）
Padiatr Padol. 1979;14(1):111-6.
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Transient, severe periventricular hypodensity after leukemic prophylaxis with cranial irradiation and intrathecal methotrexate.在进行头颅照射和鞘内注射甲氨蝶呤进行白血病预防后出现短暂的、严重的脑室周围低密度影。
J Comput Assist Tomogr. 1978 Sep;2(4):502-5. doi: 10.1097/00004728-197809000-00023.

引用本文的文献

1
Transient focal leukoencephalopathy following intraventricular methotrexate and cytarabine. A complication of the Ommaya reservoir: case report and review of the literature.
Childs Nerv Syst. 1990 Jun;6(4):231-5. doi: 10.1007/BF01850981.

本文引用的文献

1
Neurologic sequelae of methotrexate and ionizing radiation: a new classification.甲氨蝶呤与电离辐射的神经后遗症：一种新分类
Cancer Treat Rep. 1981;65 Suppl 1:89-98.
2
The development of cerebral CT changes during treatment of acute lymphocytic leukemia in childhood.儿童急性淋巴细胞白血病治疗期间脑CT变化的发展
Neuroradiology. 1981;22(2):79-84. doi: 10.1007/BF00344778.
3
Enhancement of the white matter following prophylactic therapy of the central nervous system for leukemia: radiation effects and methotrexate leukoencephalopathy.
Radiology. 1981 Aug;140(2):409-12. doi: 10.1148/radiology.140.2.6942436.
4
Computed tomography brain scans in children with acute lymphocytic leukemia receiving methotrexate alone as central nervous system prophylaxis.接受甲氨蝶呤单药作为中枢神经系统预防治疗的急性淋巴细胞白血病患儿的脑部计算机断层扫描。
Cancer. 1980 May 1;45(9):2274-8. doi: 10.1002/1097-0142(19800501)45:9<2274::aid-cncr2820450909>3.0.co;2-6.
5
CT abnormalities and altered methotrexate clearance in children with CNS leukemia.中枢神经系统白血病患儿的CT异常与甲氨蝶呤清除率改变
Neurology. 1984 Feb;34(2):229-33. doi: 10.1212/wnl.34.2.229.
6
Serial cranial computed-tomography scans in children with leukemia given two different forms of central nervous system therapy.
J Clin Oncol. 1983 Dec;1(12):793-8. doi: 10.1200/JCO.1983.1.12.793.
7
Adverse effects of intrathecal methotrexate in children with acute leukemia in remission.鞘内注射甲氨蝶呤对急性白血病缓解期儿童的不良反应。
Blood. 1975 Feb;45(2):189-95.
8
Paraplegia following intrathecal methotrexate: report of a case and review of the literature.
Cancer. 1976 Apr;37(4):1663-8. doi: 10.1002/1097-0142(197604)37:4<1663::aid-cncr2820370408>3.0.co;2-7.
9
Intracranial calcifications in childhood leukemia. An association with systemic chemotherapy.儿童白血病中的颅内钙化。与全身化疗的关联。
J Pediatr. 1977 Dec;91(6):909-13. doi: 10.1016/s0022-3476(77)80888-3.
10
Computed tomographic appearance of methotrexate-induced necrotizing leukoencephalopathy.甲氨蝶呤所致坏死性白质脑病的计算机断层扫描表现。
Radiology. 1977 Feb;122(2):377-8. doi: 10.1148/122.2.377.