儿童运动障碍的定位。
Localising movement disorders in childhood.
机构信息
Departments of Pediatrics and Neurology, Yale University, New Haven, CT, USA; Department of Cellular and Molecular Physiology, Yale University, New Haven, CT, USA; Department of Neurology, University of Washington, Seattle, WA, USA.
Departments of Pediatrics and Neurology, Yale University, New Haven, CT, USA.
出版信息
Lancet Child Adolesc Health. 2019 Dec;3(12):917-928. doi: 10.1016/S2352-4642(19)30330-X. Epub 2019 Oct 22.
The diagnosis and management of movement disorders in children can be improved by understanding the pathways, neurons, ion channels, and receptors involved in motor learning and control. In this Review, we use a localisation approach to examine the anatomy, physiology, and circuitry of the basal ganglia and highlight the mechanisms that underlie some of the major movement disorders in children. We review the connections between the basal ganglia and the thalamus and cortex, address the basic clinical definitions of movement disorders, and then place diseases within an anatomical or physiological framework that highlights basal ganglia function. We discuss how new pharmacological, behavioural, and electrophysiological approaches might benefit children with movement disorders by modifying synaptic function. A better understanding of the mechanisms underlying movement disorders allows improved diagnostic and treatment decisions.
通过了解参与运动学习和控制的途径、神经元、离子通道和受体，儿童运动障碍的诊断和治疗可以得到改善。在这篇综述中，我们使用定位方法来研究基底神经节的解剖、生理和回路，并强调了一些儿童主要运动障碍的基础机制。我们回顾了基底神经节与丘脑和皮层之间的连接，讨论了运动障碍的基本临床定义，然后将疾病置于突出基底神经节功能的解剖学或生理学框架内。我们讨论了新的药理学、行为学和电生理学方法如何通过改变突触功能使运动障碍患儿受益。对运动障碍基础机制的更好理解可有助于改善诊断和治疗决策。
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