三体性是小鼠T细胞白血病发生的原因还是结果？对罗伯逊易位小鼠的研究。
Is trisomy cause or consequence of murine T cell leukemia development? Studies on Robertsonian translocation mice.
作者信息
Spira J, Wiener F, Ohno S, Klein G
出版信息
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6619-21. doi: 10.1073/pnas.76.12.6619.
Abstract
Trypsin-Giemsa banding studies on T cell leukemias induced in Robertsonian translocation mice by dimethylbenz[a]anthracene and Moloney leukemia virus show a trisomy of chromosome 15 even in cases in which chromosome 15 has undergone centromeric fusion with chromosomes 1, 5, or 6. These results suggest that the duplication of gene(s) located on chromosome 15 is of critical importance for murine T cell leukemia development.
摘要
对由二甲基苯并[a]蒽和莫洛尼白血病病毒诱导的罗伯逊易位小鼠发生的T细胞白血病进行胰蛋白酶-吉姆萨显带研究发现，即使在15号染色体已与1、5或6号染色体发生着丝粒融合的情况下，仍存在15号染色体三体。这些结果表明，位于15号染色体上的基因重复对小鼠T细胞白血病的发展至关重要。
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