[持续非卧床腹膜透析患者头孢替安的药代动力学]

[Pharmacokinetics of cefotiam in patients undergoing continuous ambulatory peritoneal dialysis].

作者信息

Itagaki N, Hasegawa H, Tsujino M, Takahashi K, Yamamoto Y, Imada A, Horiuchi A

机构信息

Third Department of Internal Medicine, School of Medicine, Kinki University.

出版信息

Jpn J Antibiot. 1988 Apr;41(4):405-8.

PMID:3165474

Abstract

The pharmacokinetics of cefotiam (CTM) was investigated in 7 patients undergoing continuous ambulatory peritoneal dialysis (CAPD). One gram of CTM was infused either intravenously (i.v. group) or intraperitoneally (i.p. group). In the i.v. group, the serum concentration of CTM at 6 hours after infusion was 25.9 mg/L and the half-life value was 5.09 hours, while the peak value of CTM in dialysate was 12.4 mg/L. In the i.p. group without peritonitis, the dialysate concentration of CTM at 6 hours after infusion was 108.6 mg/L. The serum concentration at 15 minutes after infusion was 3.0 mg/L, the corresponding peak value was 14.0 mg/L at 4 and 6 hours after infusion.

摘要

对7例持续性非卧床腹膜透析（CAPD）患者进行了头孢替安（CTM）的药代动力学研究。1克CTM通过静脉注射（静脉注射组）或腹腔内注射（腹腔注射组）给药。在静脉注射组中，输注后6小时CTM的血清浓度为25.9毫克/升，半衰期值为5.09小时，而透析液中CTM的峰值为12.4毫克/升。在无腹膜炎的腹腔注射组中，输注后6小时CTM的透析液浓度为108.6毫克/升。输注后15分钟时血清浓度为3.0毫克/升，输注后4小时和6小时相应的峰值为14.0毫克/升。