Matsuura Y, Tamura M, Yamashina H, Higo M, Fujii T
Jpn J Antibiot. 1983 Mar;36(3):537-46.
The pharmacokinetics of intravenously administered cefotiam (CTM), using a two-compartment or three-compartment open model, have been investigated in patients undergoing thoracic surgery. Patients (Group 1) given 1 hour drip infusion of 1 g of CTM, had the peak serum level (32.8 micrograms/ml) at 1 hour, and the peak pleural effusion level (8.3 micrograms/ml) was achieved at 2.08 hours. Patients (Group 2) given an one-shot intravenous injection of 1 g of CTM, had the maximum pleural effusion concentration (8.35 micrograms/ml) at 2.67 hours. Patients (Group 3) given 1 hour drip infusion of 1 g of CTM, had the mean concentration (2.3--2.5 micrograms/g) in the pleural tissue for 2 to 3.5 hours. Clinical study comprising 20 patients was performed to evaluate the effects of CTM as a prophylactic antimicrobial agent in the thoracic surgery. Patients received intravenous administration of 4 g/day of CTM for 7--10 days. Each patients was evaluated daily for fever, signs of allergic reaction, and wound infection and so on. No infections occurred in these thoracic surgery except 1, and no serious side effects was observed in this study.
采用二室或三室开放模型，对接受胸外科手术的患者静脉注射头孢替安（CTM）的药代动力学进行了研究。接受1g CTM 1小时静脉滴注的患者（第1组），血清峰值水平（32.8微克/毫升）出现在1小时，胸腔积液峰值水平（8.3微克/毫升）出现在2.08小时。接受1g CTM单次静脉注射的患者（第2组），胸腔积液最大浓度（8.35微克/毫升）出现在2.67小时。接受1g CTM 1小时静脉滴注的患者（第3组），胸腔组织中的平均浓度（2.3 - 2.5微克/克）维持2至3.5小时。进行了一项包括20名患者的临床研究，以评估CTM作为胸外科预防性抗菌药物的效果。患者接受每天4g CTM静脉给药，持续7 - 10天。每天对每位患者进行发热、过敏反应体征和伤口感染等评估。除1例患者外，这些胸外科手术患者均未发生感染，本研究中未观察到严重副作用。
