Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove, Czech Republic.
Mini Rev Med Chem. 2020;20(15):1532-1542. doi: 10.2174/1389557519666191018170908.
Inhibitors of cholinesterases are a wide group of low molecular weight compounds with a significant role in the current pharmacology. Besides the pharmacological importance, they are also known as toxic compounds like military nerve agents. In the pharmacology, drugs for Alzheimer disease, myasthenia gravis and prophylaxis of poisoning by nerve agents can be mentioned as the relevant applications. Besides this, anti-inflammation and antiphrastic drugs are other pharmacological applications of these inhibitors. This review is focused on a survey of cholinesterase inhibitors with known or expected pharmacological impact and indications of their use. Recent literature with comments is provided here as well.
胆碱酯酶抑制剂是一类具有广泛应用前景的低分子量化合物，在当前药理学中具有重要作用。除了药理学上的重要性外，它们还被称为有毒化合物，如军用神经毒剂。在药理学中，可以提到用于治疗老年痴呆症、重症肌无力和预防神经毒剂中毒的药物作为相关应用。除此之外，抗炎和抗精神病药物也是这些抑制剂的其他药理学应用。本综述重点介绍了具有已知或预期药理学作用和用途的胆碱酯酶抑制剂的调查。这里还提供了最近带有评论的文献。
