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巴基斯坦人群中维生素D受体基因I多态性与2型糖尿病的关联

Association of Vitamin D receptor gene I polymorphism with type 2 diabetes mellitus in Pakistani population.

作者信息

Fatma Hussain, Abdul Sattar Naila

机构信息

Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad, Pakistan.

Department of Biochemistry, Government College for Women University, Faisalabad, Pakistan.

出版信息

Afr Health Sci. 2019 Jun;19(2):2164-2171. doi: 10.4314/ahs.v19i2.41.

DOI:10.4314/ahs.v19i2.41
PMID:31656501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6794500/
Abstract

BACKGROUND

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with strong genetic components. The reported association of vitamin D receptor (VDR) gene polymorphisms varies among ethnic groups.

OBJECTIVES

The present study was conducted to determine association of vitamin D receptor gene I (rs1544410 A>G) polymorphism with type 2 diabetes mellitus in Pakistani population.

METHODS

Blood samples were collected from 150 T2DM patients and 100 non-diabetic engaged by convenient sampling method. After collection of demographic data, assessment of fasting glucose (FG), vitamin D, HbA1c, renal function tests, liver function tests and lipid profile was done. Candidate gene polymorphism was analyzed by DNA amplification with polymerase chain reaction and endonuclease digestion.

RESULTS

Biochemical parameters were significantly different among case and control groups. Associations of I genotype with T2DM, related complications and biochemical variables were not significant.

CONCLUSION

The current study did not provide evidence for the association of VDR gene I polymorphism with T2DM in Pakistani population.

摘要

背景

2型糖尿病（T2DM）是一种具有强大遗传成分的复杂代谢紊乱疾病。维生素D受体（VDR）基因多态性的报道关联在不同种族群体中有所不同。

目的

本研究旨在确定维生素D受体基因I（rs1544410 A>G）多态性与巴基斯坦人群2型糖尿病的关联。

方法

采用方便抽样法从150例T2DM患者和100例非糖尿病患者中采集血样。收集人口统计学数据后，进行空腹血糖（FG）、维生素D、糖化血红蛋白（HbA1c）、肾功能检查、肝功能检查和血脂谱评估。通过聚合酶链反应和核酸内切酶消化进行DNA扩增分析候选基因多态性。

结果

病例组和对照组的生化参数有显著差异。I基因型与T2DM、相关并发症和生化变量之间的关联不显著。

结论

本研究未提供维生素D受体基因I多态性与巴基斯坦人群T2DM相关联的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f2/6794500/11304f672ef3/AFHS1902-2164Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f2/6794500/b57d1461b963/AFHS1902-2164Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f2/6794500/c4989243cca2/AFHS1902-2164Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f2/6794500/83382a3986b8/AFHS1902-2164Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f2/6794500/11304f672ef3/AFHS1902-2164Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f2/6794500/b57d1461b963/AFHS1902-2164Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f2/6794500/c4989243cca2/AFHS1902-2164Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f2/6794500/83382a3986b8/AFHS1902-2164Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71f2/6794500/11304f672ef3/AFHS1902-2164Fig2.jpg

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