Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD2 4BF, UK.
Division of Psychiatry, Edinburgh Medical School, University of Edinburgh, Edinburgh, EH10 5HF, UK.
Eur J Hum Genet. 2020 Mar;28(3):358-366. doi: 10.1038/s41431-019-0530-2. Epub 2019 Oct 29.
Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922-226,683) with depressive symptoms, major depressive disorders and neuroticism using the the cross-trait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.
疼痛表型与抑郁等精神特征以及神经质等人格特征之间的相关性尚不完全清楚。在这项研究中，我们使用 LD Hub 中集成的跨性状连锁不平衡评分回归（LDSC）方法，估计了 8 种疼痛表型（由英国生物银行定义，n=151922-226683）与抑郁症状、重度抑郁症和神经质之间的遗传相关性。我们还使用 LDSC 软件计算了疼痛表型之间的遗传相关性。除了臀部疼痛和膝盖疼痛外，所有其他疼痛表型与抑郁症状、重度抑郁症和神经质均具有显著正相关的遗传相关性。所有疼痛表型均具有遗传性，全身疼痛表现出的遗传性最高（h=0.31，标准误差=0.072）。许多疼痛表型之间存在正相关且显著的遗传相关性，表明存在共同的遗传机制。我们的研究结果表明，疼痛、神经质和抑郁共有的遗传风险因素存在部分重叠。
