Wang Lixin, Min Qiaoyun, Jiang Jingui, Shao Yuyu, Cao Yang, Yan Daxiang
Department of Pathology, Jinhu County People's Hospital, Jiangsu Province, China.
Department of Imaging, Jinhu County People's Hospital, Jiangsu Province, China.
J Coll Physicians Surg Pak. 2019 Nov;29(11):1114-1115. doi: 10.29271/jcpsp.2019.11.1114.
Low-grade nasopharyngeal papillary adenocarcinoma is a rare tumor, and only a limited number of cases are reported in the literature. The case reported in this study had long-term nasal catarrh with a runny nose and was admitted to the hospital. Computed tomography (CT) examination revealed polypoid mass in the nasopharynx. Pathological examination revealed typical papillary growth pattern of glandular epithelial cells. Immunohistochemical (IHC) staining showed the tumor cells to be diffusely positive for cytokeratin 7 (CK7), vimentin, and thyroid transcription factor 1 (TTF-1). The Ki-67 proliferation index was approximately 1%. In situ hybridization for latent Ebstein-virus (EBV) injection was negative. The patient did not exhibit recurrence or metastasis of the tumor.
低级别鼻咽乳头状腺癌是一种罕见肿瘤，文献中仅报道了有限数量的病例。本研究报道的病例有长期鼻黏膜炎伴流涕症状并入院治疗。计算机断层扫描（CT）检查显示鼻咽部有息肉样肿物。病理检查显示腺上皮细胞呈典型的乳头状生长模式。免疫组织化学（IHC）染色显示肿瘤细胞对细胞角蛋白7（CK7）、波形蛋白和甲状腺转录因子1（TTF-1）呈弥漫性阳性。Ki-67增殖指数约为1%。潜伏性爱泼斯坦-巴尔病毒（EBV）感染的原位杂交检测为阴性。该患者未出现肿瘤复发或转移。
