Department of Otorhinolaryngology, Chi Mei Medical Center, Tainan, Taiwan.
Department of Optometry, Chung Hwa University of Medical Technology, Taiwan.
Medicine (Baltimore). 2021 Nov 5;100(44):e27729. doi: 10.1097/MD.0000000000027729.
Primary nasopharyngeal papillary adenocarcinoma is a rare nasopharyngeal neoplasm with a good prognosis and a low propensity for regional recurrence. To date, only few cases of primary nasopharyngeal papillary adenocarcinoma have been reported in the literature.
A 24-year-old female patient presented with intermittent hemoptysis and blood tinge nasal discharge.
An exophytic and pedunculated mass over the roof of the nasopharynx was found on nasopharyngoscope. Biopsy was done and the pathology confirmed well-differentiated primary nasopharyngeal papillary adenocarcinoma, strongly positive for CK7, and transcription termination factor 1; but negative for thyroglobulin. The final diagnosis was primary nasopharyngeal papillary adenocarcinoma, well-differentiated, pT1N0M0, stage I.
The patient underwent excision of nasopharyngeal tumor under sinuscopic assistance.
: No local recurrence or distant metastasis was noted during the 6 months of follow-up.
We aim at highlighting the importance of a thorough differential diagnosis of nasopharyngeal tumor. Further investigation is still needed for providing evidence to standardize the treatment protocol.
原发性鼻咽部乳头状腺癌是一种罕见的鼻咽部肿瘤，预后良好，区域复发倾向低。迄今为止，文献中仅报道了少数几例原发性鼻咽部乳头状腺癌病例。
一名 24 岁女性患者出现间歇性咯血和带血丝的鼻涕。
鼻咽喉镜检查发现鼻咽顶部有外生性和带蒂的肿块。进行了活检，病理证实为分化良好的原发性鼻咽部乳头状腺癌，CK7 和转录终止因子 1 强阳性；甲状腺球蛋白阴性。最终诊断为分化良好的原发性鼻咽部乳头状腺癌，pT1N0M0，Ⅰ期。
患者在鼻窦镜辅助下接受了鼻咽肿瘤切除术。
随访 6 个月期间，未发现局部复发或远处转移。
我们旨在强调对鼻咽肿瘤进行彻底鉴别诊断的重要性。进一步的研究仍需要提供证据来规范治疗方案。
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