Fu Chia-Hsiang, Chang Kai-Ping, Ueng Shir-Hwa, Wu Chia-Chen, Hao Sheng-Po
Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan.
Auris Nasus Larynx. 2008 Dec;35(4):579-82. doi: 10.1016/j.anl.2007.10.009. Epub 2008 Feb 21.
Thyroid-like papillary adenocarcinoma is an extremely rare neoplasm in the nasopharynx. We present a case with a pedunculated tumor in the nasopharyngeal vault and the preoperative biopsy revealed a thyroid-like papillary adenocarcinoma. Complete tumor resection via modified facial translocation was undergone subsequently. Postoperative histopathological examinations and immunohistochemical studies confirmed the diagnosis. Regarding the association with Epstein-Barr virus (EBV), the tumor was negative for both small EBV-encoded RNA (EBER) and EBV latent membrane protein-1 (LMP-1) oncogene. This rare neoplasm demonstrated a distinct etiology and nature from typical nasopharyngeal carcinomas and should be managed mainly by surgical resection.
甲状腺样乳头状腺癌是鼻咽部一种极其罕见的肿瘤。我们报告一例鼻咽顶有蒂肿瘤的病例，术前活检显示为甲状腺样乳头状腺癌。随后通过改良面部移位术进行了肿瘤全切。术后组织病理学检查和免疫组化研究证实了诊断。关于与爱泼斯坦-巴尔病毒（EBV）的关联，肿瘤的小EBV编码RNA（EBER）和EBV潜伏膜蛋白-1（LMP-1）癌基因均为阴性。这种罕见肿瘤与典型鼻咽癌的病因和性质不同，主要应通过手术切除进行治疗。
