不稳定型心绞痛患者血清白细胞介素-18与冠状动脉疾病程度

Serum interleukin-18 and extent of coronary artery disease in unstable angina.

作者信息

Sadeghi Masoumeh, Gheraati Maryam, Soleimani Azam, Amirpour Afshin, Taheri Marzieh, Yazdekhasti Safoura, Valikhani Elham

机构信息

Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

ARYA Atheroscler. 2018 May;14(3):122-127. doi: 10.22122/arya.v14i3.1370.

DOI:10.22122/arya.v14i3.1370

PMID:30349574

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6191574/

Abstract

BACKGROUND

Interleukin-18 (IL-18) is an inflammatory marker with challenging role in atherosclerosis. The present study was carried out aiming to evaluate the association between IL-18 serum level and extent and severity of atherosclerosis among young patients with unstable angina (UA) who underwent coronary angiography.

METHODS

This cross sectional study was performed from July to October 2015 in Chamran heart center, Isfahan, Iran. 180 patients with UA in the age range of below 50 years entered the study. All demographic, past history, physical examination, electrocardiogram (EKG or ECG), and transthoracic echocardiogram (TTE) data were collected. Serum level of IL-18 was measured using enzyme-linked immunosorbent assay (ELISA) method. A coronary angiography was performed on all patients to evaluate the presence and the incidence rate of coronary artery disease (CAD).

RESULTS

Mean age of the patients was 46.0 ± 4.6 years [47.4 ± 4.3 and 45.9 ± 4.9 among patients with CAD and normal coronary, respectively (P = 0.040)]. Rate of severe CAD was greater among men compared to women with values 67.8% and 51.8%, respectively (P = 0.032). The median [interquartile range (IQR)] value of serum IL-18 among patients with CAD [192.86 (128.03,325.75)] was higher than normal coronary subjects [172.81 (139.77,243.21)], however it was not significant (198.4 ± 93.5, P = 0.287). A significant difference between serum IL-18 level and number of stenosis vessels was detected only among women (P = 0.032).

CONCLUSION

Serum IL-18 level can predict the number of coronary arteries with significant stenosis among women with unstable angina.

摘要

背景

白细胞介素-18（IL-18）是一种炎症标志物，在动脉粥样硬化中发挥着具有挑战性的作用。本研究旨在评估接受冠状动脉造影的不稳定型心绞痛（UA）年轻患者中IL-18血清水平与动脉粥样硬化程度和严重程度之间的关联。

方法

本横断面研究于2015年7月至10月在伊朗伊斯法罕的查姆兰心脏中心进行。180例年龄在50岁以下的UA患者进入研究。收集了所有人口统计学、既往史、体格检查、心电图（EKG或ECG）和经胸超声心动图（TTE）数据。采用酶联免疫吸附测定（ELISA）法测定IL-18血清水平。对所有患者进行冠状动脉造影以评估冠状动脉疾病（CAD）的存在和发病率。

结果

患者的平均年龄为46.0±4.6岁[CAD患者和冠状动脉正常患者分别为47.4±4.3岁和45.9±4.9岁（P = 0.040）]。男性严重CAD的发生率高于女性，分别为67.8%和51.8%（P = 0.032）。CAD患者血清IL-18的中位数[四分位间距（IQR）]值[192.86（128.03，325.75）]高于冠状动脉正常受试者[172.81（139.77，243.21）]，但差异无统计学意义（198.4±93.5，P = 0.287）。仅在女性中检测到血清IL-18水平与狭窄血管数量之间存在显著差异（P = 0.032）。