Lu Jingjing, Wang Xiaomin, Lin Leesa, Xuan Ziming, Hu Yanhong Jessika, Zhou Xudong
Institute of Social Medicine, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Department of Public Health, Environments and Society, Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London WC1H 9SH, UK.
Antibiotics (Basel). 2019 Oct 28;8(4):200. doi: 10.3390/antibiotics8040200.
This study aims to explore how changes in external factors caused by migration impact antibiotic use behaviors among Chinese university students in comparison to their peers from host areas and origin areas. Migration status was determined by host universities and origin areas, which were broadly defined as eastern vs. western regions in China.
This study analyzed secondary data from a cross-sectional study conducted in China about the antibiotic use behaviors of university students in 2015. Students were divided into four groups: eastern local students (E-Es), western local students (W-Ws), eastern-western migrant students (E-Ws), and western-eastern migrant students (W-Es).
After controlling for gender, grade, major, hometown (rural or urban), and parents' education, E-Ws reported a significantly higher odds of asking for antibiotics (OR = 2.13; 95% CI = 1.54-3.03; < 0.001) and taking antibiotics prophylactically (OR = 1.85; 95% CI = 1.32-2.56; < 0.001) compared with E-Es; W-Es reported a significantly lower odds of asking for antibiotics (OR = 0.56; 95% CI = 0.37-0.83; < 0.01) and taking antibiotics prophylactically (OR = 0.57; 95% CI = 0.41-0.81; < 0.01) compared with W-Ws.
Regional differences likely interacted with students' migration status in forming different antibiotic use behaviors. Factors including financial incentives and loose regulations of antibiotic over-prescription by health providers and peer influence may contribute to worsened antibiotic use behaviors among E-Ws.
本研究旨在探讨与来自接收地区和原籍地区的同龄人相比，迁移所导致的外部因素变化如何影响中国大学生的抗生素使用行为。迁移状态由接收大学和原籍地区决定，大致定义为中国的东部地区与西部地区。
本研究分析了2015年在中国进行的一项关于大学生抗生素使用行为的横断面研究的二手数据。学生被分为四组：东部本地学生（E-Es）、西部本地学生（W-Ws）、东西部迁移学生（E-Ws）和西东部迁移学生（W-Es）。
在控制了性别、年级、专业、家乡（农村或城市）以及父母教育程度后，与E-Es相比，E-Ws报告索要抗生素的几率显著更高（OR = 2.13；95%CI = 1.54 - 3.03；<0.001）以及预防性使用抗生素的几率显著更高（OR = 1.85；95%CI = 1.32 - 2.56；<0.001）；与W-Ws相比，W-Es报告索要抗生素的几率显著更低（OR = 0.56；95%CI = 0.37 - 0.83；<0.01）以及预防性使用抗生素的几率显著更低（OR = 0.57；95%CI = 0.41 - 0.81；<0.01）。
地区差异可能在形成不同的抗生素使用行为方面与学生的迁移状态相互作用。包括经济激励、医疗服务提供者对抗生素过度处方的宽松监管以及同伴影响等因素可能导致E-Ws的抗生素使用行为恶化。
