Machado Nikita N, Wilhelm Scott M
Department of Surgery, University Hospitals Conneaut, Conneaut, OH 44030, USA.
Department of Surgery, Endocrine Surgery, University Hospitals Cleveland, University Hospitals, Cleveland, OH 44106, USA.
Cancers (Basel). 2019 Oct 28;11(11):1676. doi: 10.3390/cancers11111676.
Parathyroid cancer is one of the rarest causes of primary hyperparathyroidism and tends to present with more severe symptoms than its more benign counterparts. This article details various aspects of the disease process, including epidemiology, clinical presentation, and a step-wise diagnostic process for parathyroid cancer. This includes laboratory assessments as well as a proposed staging system. The en bloc principle of surgical intervention is detailed, as well as the current role of adjuvant treatments. A general guide to surveillance and the natural history of the disease is also outlined.
甲状旁腺癌是原发性甲状旁腺功能亢进最罕见的病因之一，与相对良性的同类疾病相比，其症状往往更为严重。本文详细介绍了该疾病过程的各个方面，包括流行病学、临床表现以及甲状旁腺癌的逐步诊断过程。这包括实验室评估以及提议的分期系统。详细阐述了手术干预的整块切除原则以及辅助治疗的当前作用。还概述了疾病监测和自然史的一般指南。
