素食主义作为亚洲人无症状结肠憩室病的保护因素：一项回顾性横断面和病例对照研究。
Vegetarianism as a protective factor for asymptomatic colonic diverticulosis in Asians: a retrospective cross-sectional and case-control study.
作者信息
Bong Jihun, Kang Hyoun Woo, Cho Hyeki, Nam Ji Hyung, Jang Dong Kee, Kim Jae Hak, Lee Jun Kyu, Lim Yun Jeong, Koh Moon-Soo, Lee Jin Ho
机构信息
Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
出版信息
Intest Res. 2020 Jan;18(1):121-129. doi: 10.5217/ir.2019.00106. Epub 2019 Nov 1.
BACKGROUND/AIMS: Dietary fiber intake is considered a protective factor for diverticular disease such as diverticulitis. However, evidence for an inverse connection between dietary fiber consumption and asymptomatic colonic diverticulosis is lacking. Specifically, few studies have investigated this subject in Asians with different presentations of diverticulosis. Therefore, we assessed the protective effects of a vegetarian diet for asymptomatic colonic diverticulosis in Buddhist monks who are obligatory vegetarians for spiritual reasons compared with the general population.
METHODS
A retrospective, cross-sectional, case-control study was conducted in age- and sex-matched Buddhist monks and the general population who underwent colonoscopy for screening at a Korean health promotion center from August 2005 to June 2018. We compared the prevalence of asymptomatic diverticulosis between the 2 groups using a self-administered questionnaire.
RESULTS
In this study, a total of 1,316 individuals were included (Buddhist monks of 658 and general population of 658) with a mean age of 52.6±9.5 years. The prevalence of asymptomatic diverticulosis in Buddhist monks was lower compared with the general population (6.7% [44/658] vs. 10.8% [71/658], P=0.008). Buddhist monks had a higher rate of high body mass index (BMI) and metabolic syndrome. By a multivariate regression analysis model, a nonvegetarian diet (odds ratio [OR], 1.82; 95% confidence interval [CI], 1.21-2.72, P=0.004), old age (OR, 4.53; 95% CI, 1.36-15.12; P=0.014), male sex (OR, 1.91; 95% CI, 1.28-2.85; P=0.002), and a high BMI (OR, 1.50; 95% CI, 1.01-2.23; P=0.047) were independent predictors of asymptomatic diverticulosis. Moreover, a nonvegetarian diet was associated with both right-sided and left-sided diverticulosis.
CONCLUSIONS
A nonvegetarian diet may increase a risk of asymptomatic colonic diverticulosis in Asians.
背景/目的：膳食纤维摄入被认为是憩室病（如憩室炎）的保护因素。然而，缺乏膳食纤维摄入与无症状结肠憩室病之间存在负相关的证据。具体而言，很少有研究在不同表现的憩室病亚洲人中调查这一主题。因此，我们评估了素食对无症状结肠憩室病的保护作用，将出于精神原因而必须吃素的佛教僧侣与普通人群进行比较。
方法
2005年8月至2018年6月，在韩国一家健康促进中心对年龄和性别匹配的佛教僧侣和接受结肠镜筛查的普通人群进行了一项回顾性横断面病例对照研究。我们使用自行填写的问卷比较了两组无症状憩室病的患病率。
结果
本研究共纳入1316人（佛教僧侣658人，普通人群658人），平均年龄52.6±9.5岁。佛教僧侣中无症状憩室病的患病率低于普通人群（6.7%[44/658]对10.8%[71/658]，P=0.008）。佛教僧侣的高体重指数（BMI）和代谢综合征发生率较高。通过多变量回归分析模型，非素食饮食（比值比[OR]，1.82；95%置信区间[CI]，1.21-2.72，P=0.004）、老年（OR，4.53；95%CI，1.36-15.12；P=0.014）、男性（OR，1.91；95%CI，1.28-2.85；P=0.002）和高BMI（OR，1.50；95%CI，1.01-2.23；P=0.047）是无症状憩室病的独立预测因素。此外，非素食饮食与右侧和左侧憩室病均相关。
结论
非素食饮食可能会增加亚洲人患无症状结肠憩室病的风险。
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