Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil XII, Creteil, France
Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil XII, Creteil, France.
Br J Ophthalmol. 2020 Aug;104(8):1057-1063. doi: 10.1136/bjophthalmol-2019-315189. Epub 2019 Oct 29.
To evaluate the long-term progression of quiescent type 1 choroidal neovascularisation (CNV) associated with age-related macular degeneration (AMD) or with pachychoroid disease.
All cases of quiescent type 1 CNV with a minimum follow-up of 12 months seen at the Department of Ophthalmology of University Paris Est, Creteil and at the Centre Ophtalmologique de l'Odeon, Paris, between June 2009 and December 2018 were retrospectively reviewed. Optical coherence tomography angiography (OCT-A) of eyes not showing CNV activation during 24 months was evaluated for quantitative analyses of CNV status biomarkers (fractal dimension, lacunarity, vessel density, aspect ratio, CNV area).
A total of 67 eyes (65 patients, 43 females, mean age 76.63±9.7 years) with quiescent CNV and a mean follow-up of 49.56±27.3 (12-112) months were included. Of 28 eyes showing activation of quiescent CNV, 12 eyes with pachychoroid-associated CNV showed reduced visual loss (-3.28 ETDRS letters, p=0.7 vs -13.03 ETDRS letters, p=0.02), greater choroidal thinning (-59.5 µm, p=0.03 vs - 16.36 µm, p=0.3) and needed less antivascular endothelial growth factor intravitreal injections (IVI) (0.09 vs 0.21, p=0.01) than 16 eyes with AMD-associated CNV. CNV area was the only OCT-A biomarker to significantly change during 24 months in inactive quiescent CNV (+29.5%, p=0.01, in pachychoroid group and +27.1%, p=0.03, in the AMD group).
In the long-term follow-up, inactive quiescent CNV showed an increase of CNV area without significant changes of the other OCT-A biomarkers. Quiescent type 1 CNV undergoing activation showed greater response to IVI when associated to pachychoroid.
评估与年龄相关性黄斑变性（AMD）或厚脉络膜疾病相关的静止型 1 型脉络膜新生血管（CNV）的长期进展。
回顾性分析 2009 年 6 月至 2018 年 12 月期间在巴黎东部大学眼科系和巴黎 Odeon 眼科中心就诊的至少随访 12 个月的静止型 1 型 CNV 所有病例。对 24 个月内未出现 CNV 激活的眼进行光学相干断层扫描血管造影（OCT-A）定量分析，以评估 CNV 状态生物标志物（分形维数、空隙度、血管密度、长宽比、CNV 面积）。
共纳入 67 只眼（65 例患者，43 例女性，平均年龄 76.63±9.7 岁）的静止型 CNV，平均随访时间为 49.56±27.3（12-112）个月。在 28 只出现静止型 CNV 活动的眼中，12 只伴有厚脉络膜相关 CNV 的眼视力丧失减少（-3.28 ETDRS 字母，p=0.7 与-13.03 ETDRS 字母，p=0.02），脉络膜变薄更明显（-59.5μm，p=0.03 与-16.36μm，p=0.3），需要的抗血管内皮生长因子玻璃体内注射（IVI）更少（0.09 与 0.21，p=0.01），而 16 只与 AMD 相关的 CNV 则更多。在 24 个月的无活性静止型 CNV 中，CNV 面积是唯一显著变化的 OCT-A 生物标志物（厚脉络膜组增加 29.5%，p=0.01，AMD 组增加 27.1%，p=0.03）。
在长期随访中，无活性静止型 CNV 的 CNV 面积增加，而其他 OCT-A 生物标志物无明显变化。静止型 1 型 CNV 发生活动时，与厚脉络膜相关时对 IVI 的反应更大。
