Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Department of Surgery, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
BMJ Open. 2019 Oct 28;9(10):e031742. doi: 10.1136/bmjopen-2019-031742.
Inguinal hernia mesh repair is the standard care for symptomatic inguinal hernia. Mesh fixation is used to keep mesh in place for which various mesh fixation techniques have been used in open and laparoscopic inguinal hernia repair, but their effectiveness has remained inconclusive. Therefore, we developed a protocol for an umbrella review in order to summarise the evidences with integrate and update data of different mesh fixation techniques in both open and laparoscopic inguinal hernia repair.
Previous systematic reviews and meta-analyses will be identified from Medline, Scopus, Cochrane Databases, EMBASE, Database of Abstracts of Reviews of Effects, PROSPERO Register, CINAHL, JBISRIS, EPPI-Centre, Wiley Online Library and Science Direct database. Two reviewers will independently determine studies for eligibility. Disagreement will be solved by consensus and arbitrated by the third reviewer. Data extraction will also be performed by two independent reviewers. For umbrella review, a descriptive analysis will be applied to describe evidence of mesh fixation effectiveness. Overlapping studies and excess significance test will be performed to assess whether previous evidences are bias. In addition, individual studies from meta-analysis and additional published studies will be pooled using network meta-analyses. We will use I statistic and Cochran's Q test to assess heterogeneity. Risk of bias and publication bias, if appropriate, will be evaluated, as well as overall strength of the evidence.
This protocol has been registered with PROSPERO and approved with Institutional Review Board, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand (COA 167/2018). The results will be published in peer-reviewed journal.
CRD42018111773.
腹股沟疝网片修补术是治疗有症状腹股沟疝的标准治疗方法。网片固定用于将网片固定在适当的位置，为此，已在开放式和腹腔镜腹股沟疝修补术中使用了各种网片固定技术，但它们的效果仍不确定。因此，我们制定了一项伞式综述方案，以总结不同网片固定技术在开放式和腹腔镜腹股沟疝修补术中的证据，并整合和更新数据。
将从 Medline、Scopus、Cochrane 数据库、EMBASE、效应摘要数据库、PROSPERO 登记处、CINAHL、JBISRIS、EPPICentre、Wiley Online Library 和 Science Direct 数据库中确定以前的系统评价和荟萃分析。两名评审员将独立确定研究的合格性。如有分歧，将通过协商解决，并由第三名评审员仲裁。数据提取也将由两名独立的评审员进行。对于伞式综述，将进行描述性分析以描述网片固定有效性的证据。将进行重叠研究和过度显著性检验，以评估以前的证据是否存在偏倚。此外，将使用网络荟萃分析对荟萃分析中的个体研究和额外发表的研究进行汇总。我们将使用 I 统计量和 Cochran's Q 检验来评估异质性。如果适用，将评估偏倚风险和发表偏倚，并评估证据的总体强度。
本方案已在 PROSPERO 上注册，并获得泰国曼谷纳瓦明德拉医院玛希隆大学医学系机构审查委员会的批准（COA 167/2018）。研究结果将发表在同行评议的期刊上。
PROSPERO 注册号：CRD42018111773。
